Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Methodol. Mar 20, 2024; 14(1): 88518
Published online Mar 20, 2024. doi: 10.5662/wjm.v14.i1.88518
Rikkunshito increases peripheral incretin-hormone levels in humans and rats
Hiroshi Kono, Shinji Furuya, Hidenori Akaike, Katsutoshi Shoda, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Daisuke Ichikawa
Hiroshi Kono, Shinji Furuya, Hidenori Akaike, Katsutoshi Shoda, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Daisuke Ichikawa, The First Department of Surgery, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan
Author contributions: Kono H conducting and organizing this experiment; Furuya S, assessment of samples; Akaike H, assessment of samples; Shoda K, analyzing the data; Kawaguchi Y, analyzing the data; Amemiya H, assessment of samples; Kawaida H, collecting samples; Ichikawa D advising for these experiments.
Institutional review board statement: This study was reviewed and approved by the University of Yamanashi Hospital, Institutional Review Board: ID No. 820.
Institutional animal care and use committee statement: This study is approved by the Institutional Animal Care and Committee.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at (hkouno@yamanashi.ac.jp). Participants gave informed consent for data sharing.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hiroshi Kono, MD, PhD, Adjunct Associate Professor, The First Department of Surgery, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan. hkouno@yamanashi.ac.jp
Received: September 29, 2023
Peer-review started: September 29, 2023
First decision: December 6, 2023
Revised: December 27, 2023
Accepted: February 3, 2024
Article in press: February 3, 2024
Published online: March 20, 2024
Processing time: 160 Days and 1.2 Hours
Core Tip

Core Tip: This study aimed to investigate the effects of rikkunshito (TJ-43) on gastrointestinal hormones, including gastric inhibitory polypeptide and glucagon-like peptide-1, in humans and rats. As a result, TJ-43 increased incretin hormones, and insulin expression, and suppressed increases in blood glucose levels in human and animal models. Thus, TJ-43 may provide benefits after pancreatic surgery.