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World J Methodol. Dec 20, 2025; 15(4): 107411
Published online Dec 20, 2025. doi: 10.5662/wjm.v15.i4.107411
Utility of splenic transient elastography in assessing the presence of portal hypertension: A review
Mohammed Abdulrasak, Mustafa Ahmed, Sohail Hootak
Mohammed Abdulrasak, Sohail Hootak, Department of Clinical Sciences, Lund University, Malmo 22100, Sweden
Mohammed Abdulrasak, Sohail Hootak, Department of Gastroenterology and Nutrition, Skane University Hospital, Malmo 21428, Sweden
Mustafa Ahmed, Department of Gastroenterology, Helsingborg Hospital, Helsingborg 25437, Skåne, Sweden
Author contributions: Abdulrasak M contributed to conceptualization, literature review, drafting of the manuscript, critical revisions, and final approval; Ahmed M contributed to the data collection, literature review, assistance with drafting, and critical revision of the manuscript; Hootak S contributed to the critical review of methodology, input on clinical relevance, manuscript editing, and final approval; All authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammed Abdulrasak, MD, MRCP, PhD, Department of Gastroenterology and Nutrition, Skane University Hospital, Malmo 21428, Sweden. mohammed.abdulrasak@med.lu.se
Received: March 24, 2025
Revised: April 13, 2025
Accepted: May 18, 2025
Published online: December 20, 2025
Processing time: 135 Days and 1.4 Hours
Abstract

Portal hypertension (PH) is a major complication of chronic liver disease, often leading to serious clinical consequences such as variceal bleeding, ascites, and splenomegaly. The current gold standard for PH diagnosis, namely, hepatic venous pressure gradient measurement, is invasive and not widely available. Transient elastography has emerged as a non-invasive alternative for assessing liver stiffness (LS), and recent studies have highlighted the potential role of splenic stiffness (SS) in evaluating PH severity. This narrative review summarizes the available evidence on the utility of splenic transient elastography in assessing PH. We evaluated its diagnostic accuracy, technical challenges, and clinical applications, particularly in distinguishing between cirrhotic PH (CPH) and non-cirrhotic PH (NCPH). A comprehensive literature search was conducted using the PubMed database, focusing on studies that assess splenic elastography in the diagnosis and prognosis of PH. This review compares splenic elastography with other non-invasive imaging modalities, including MR elastography and shear-wave elastography. Additionally, we examined the role of SS using elastography in predicting the presence of esophageal varices and its potential impact on reducing the need for endoscopic screening. Studies have demonstrated that splenic elastography correlates well with PH severity, with cut-off values ranging between 45 kPa and 50 kPa for significant PH detection. Splenic elastography, when combined with platelet count and LS measurements, improves diagnostic accuracy and risk stratification for the occurrence of variceal bleeding. Despite its clinical promise, technical challenges such as patient positioning, body habitus, and probe selection remain key limitations. Notably, splenic elastography may be particularly useful in diagnosing NCPH, where LS remains normal but PH is present. Splenic transient elastography is a valuable adjunct in the non-invasive assessment of PH. Its ability to predict varices, differentiate between CPH and NCPH, and reduce unnecessary endoscopies suggests that it should be incorporated into routine hepatology practice. Future research should focus on refining SS cut-offs, evaluating its cost-effectiveness, and integrating splenic elastography into clinical guidelines for PH management.

Keywords: Portal hypertension; Transient elastography; Splenic stiffness; Cirrhosis; Non-cirrhotic portal hypertension; Gastroesophageal varices; Liver fibrosis

Core Tip: Splenic transient elastography is a valuable adjunct in the non-invasive assessment of portal hypertension. Its ability to predict varices, differentiate between cirrhotic and non-cirrhotic portal hypertension, and reduce unnecessary endoscopies suggests it should be incorporated into routine hepatology practice.