Renal elasticity assessment in patients of glomerulonephritis by shear-wave elastography and its correlation with histopathology and renal biomarkers

doi:10.5527/wjn.v15.i1.116148

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Mar 25, 2026 (publication date) through Mar 14, 2026

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Nephrol. Mar 25, 2026; 15(1): 116148
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.116148

Table 1 Shear wave elastography values across interstitial fibrosis and tubular atrophy grades

IF/TA grade	Mean SWE (kPa)	SD	Mean SWE (m/s)	SD
No fibrosis (A)	13.35	1.37	2.09	0.11
Mild fibrosis (B)	21.66	4.50	2.66	0.28
Moderate fibrosis (C)	28.57	4.91	3.06	0.28
Marked fibrosis (D)	40.31	5.06	3.63	0.24
P value	< 0.001		< 0.001

IF/TA: Interstitial fibrosis and tubular atrophy; SWE: Shear wave elastography.

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Table 2 Serum transforming growth factor-β1 levels across interstitial fibrosis and tubular atrophy grades

IF/TA grade	Mean TGF-β1 (pg/mL)	SD
No fibrosis (A)	11918.18	7636.16
Mild fibrosis (B)	11100.73	6089.92
Moderate fibrosis (C)	12433.00	6800.01
Marked fibrosis (D)	15438.10	7647.07
P value	1.0

IF/TA: Interstitial fibrosis and tubular atrophy; TGF-β1: Transforming growth factor-β1.

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Citation: Prasad R, Verma R, Singh A, Behera MR, Yachha M, Kushwaha RS, Jain M, Agrawal V, Yadav P, Lal H. Renal elasticity assessment in patients of glomerulonephritis by shear-wave elastography and its correlation with histopathology and renal biomarkers. World J Nephrol 2026; 15(1): 116148
URL: https://www.wjgnet.com/2220-6124/full/v15/i1/116148.htm
DOI: https://dx.doi.org/10.5527/wjn.v15.i1.116148