Sodium-glucose cotransporter-2 inhibitors beyond glycemic control: Their role in acute kidney injury recovery

doi:10.5527/wjn.v14.i4.112302

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Dec 25, 2025; 14(4): 112302
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.112302

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Figure 1 Reno-protective mechanism of sodium-glucose cotransporter-2 inhibitors in acute kidney injury recovery current clinical evidence on sodium-glucose cotransporter-2 inhibitors in acute kidney injury. ROS: Reactive oxygen species; AMPK: Adenosine monophosphate-activated protein kinase; SIRT1: Silent information regulator sirtuin 1; IL-5: Interleukin-5; IL-18: Interleukin-18; HsCRP: High sensitivity C-reactive protein; TNF-α: Tumour necrosis factor alpha; SGLT2: Sodium-glucose cotransport protein 2.

Citation: Ahsan MU, Iftikhar S, Ambreen UE, Nazir F, Fawad M, Nasir K, Leghari UR. Sodium-glucose cotransporter-2 inhibitors beyond glycemic control: Their role in acute kidney injury recovery. World J Nephrol 2025; 14(4): 112302
URL: https://www.wjgnet.com/2220-6124/full/v14/i4/112302.htm
DOI: https://dx.doi.org/10.5527/wjn.v14.i4.112302