Hara T, Suzuki K, Wakita N, Okamura Y, Ueki H, Bando Y, Terakawa T, Hyodo Y, Chiba K, Teishima J, Yao A, Miyake H. Renal functional and surgical outcomes after robot-assisted partial nephrectomy for hilar vs non-hilar tumors: Trifecta and pentafecta evaluation. World J Nephrol 2026; 15(3): 119576 [DOI: 10.5527/wjn.119576]
Corresponding Author of This Article
Takuto Hara, MD, PhD, Department of Urology, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 6500017, Hyōgo, Japan. supermarimo85@carp.kobe-u.ac.jp
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
research-article
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Hara T, Suzuki K, Wakita N, Okamura Y, Ueki H, Bando Y, Terakawa T, Hyodo Y, Chiba K, Teishima J, Yao A, Miyake H. Renal functional and surgical outcomes after robot-assisted partial nephrectomy for hilar vs non-hilar tumors: Trifecta and pentafecta evaluation. World J Nephrol 2026; 15(3): 119576 [DOI: 10.5527/wjn.119576]
Takuto Hara, Kotaro Suzuki, Naoto Wakita, Yasuyoshi Okamura, Hideto Ueki, Yukari Bando, Tomoaki Terakawa, Yoji Hyodo, Koji Chiba, Jun Teishima, Akihisa Yao, Hideaki Miyake, Department of Urology, Kobe University Graduate School of Medicine, Kobe 6500017, Hyōgo, Japan
Author contributions: Hara T contributed to conceptualization, data curation, formal analysis, methodology, investigation, and original draft; Suzuki K, Wakita N, Okamura Y, Ueki H, Bando Y, Terakawa T, Hyodo Y, Chiba K, Teishima J, Yao A, and Miyake H contributed to the review and editing of the manuscript; Miyake H contributed to supervision. All authors have read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Kobe University (approval No. B230143).
Informed consent statement: Informed consent was obtained through an opt-out procedure approved by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data supporting the findings of this study are not publicly available due to privacy and ethical restrictions. Data may be available from the corresponding author upon reasonable request and subject to approval by the Institutional Review Board.
Corresponding author: Takuto Hara, MD, PhD, Department of Urology, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 6500017, Hyōgo, Japan. supermarimo85@carp.kobe-u.ac.jp
Received: February 3, 2026 Revised: February 18, 2026 Accepted: April 3, 2026 Published online: September 25, 2026 Processing time: 194 Days and 23.1 Hours
Core Tip
Core Tip: This retrospective cohort study evaluated surgical and renal functional outcomes of robot-assisted partial nephrectomy for hilar and non-hilar renal tumors using trifecta and pentafecta metrics. While trifecta reflects perioperative quality, pentafecta incorporates renal functional preservation and chronic kidney disease progression, which are clinically relevant from a nephrological perspective. Using propensity score matching and multivariate analysis, we demonstrate that robot-assisted partial nephrectomy can achieve comparable pentafecta outcomes in hilar and non-hilar tumors when tumor complexity and surgical experience are appropriately considered, supporting the feasibility of nephron-sparing surgery for anatomically complex hilar tumors.
