Sevik C, Erbin A, Canat HL. Integrating Modified National Early Warning Score 2, computed tomography staging, and laboratory markers for enhanced prognostic stratification in emphysematous pyelonephritis. World J Nephrol 2026; 15(1): 113952 [DOI: 10.5527/wjn.v15.i1.113952]
Corresponding Author of This Article
Akif Erbin, Associate Professor, Department of Urology, Health Science University (Turkey), Basaksehir Çam and Sakura City Hospital, G-434 Street, Istanbul 34300, Türkiye. akiferbin@hotmail.com
Research Domain of This Article
Urology & Nephrology
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Letter to the Editor
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Mar 25, 2026 (publication date) through Mar 14, 2026
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Publication Name
World Journal of Nephrology
ISSN
2220-6124
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Sevik C, Erbin A, Canat HL. Integrating Modified National Early Warning Score 2, computed tomography staging, and laboratory markers for enhanced prognostic stratification in emphysematous pyelonephritis. World J Nephrol 2026; 15(1): 113952 [DOI: 10.5527/wjn.v15.i1.113952]
World J Nephrol. Mar 25, 2026; 15(1): 113952 Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.113952
Integrating Modified National Early Warning Score 2, computed tomography staging, and laboratory markers for enhanced prognostic stratification in emphysematous pyelonephritis
Cagri Sevik, Akif Erbin, Halil Lutfi Canat
Cagri Sevik, Akif Erbin, Halil Lutfi Canat, Department of Urology, Health Science University (Turkey), Basaksehir Çam and Sakura City Hospital, Istanbul 34300, Türkiye
Author contributions: Sevik C, Erbin A, and Canat HL contributed to study concept and design, data analysis, drafting of manuscript, and critical revision of the manuscript. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Akif Erbin, Associate Professor, Department of Urology, Health Science University (Turkey), Basaksehir Çam and Sakura City Hospital, G-434 Street, Istanbul 34300, Türkiye. akiferbin@hotmail.com
Received: September 9, 2025 Revised: October 20, 2025 Accepted: December 25, 2025 Published online: March 25, 2026 Processing time: 186 Days and 22.6 Hours
Core Tip
Core Tip: Emphysematous pyelonephritis is a rapidly progressive and life-threatening infection that necessitates timely and precise prognostic evaluation. Although the Modified National Early Warning Score 2 provides valuable risk information based exclusively on physiological parameters, clinical deterioration typically manifests at a relatively advanced stage. In contrast, computed tomography based staging and critical laboratory indicators, including anemia, thrombocytopenia, leukocytosis, and hyperglycemia, may yield earlier prognostic insights before overt vital-sign abnormalities develop. A combined assessment incorporating Modified National Early Warning Score 2, computed tomography classification, and laboratory indicators may therefore improve early risk stratification, inform timely nephrectomy decisions in high-risk patients, and ultimately optimize clinical outcomes.
