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World J Nephrol. Mar 25, 2026; 15(1): 108432
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.108432
Published online Mar 25, 2026. doi: 10.5527/wjn.v15.i1.108432
Diabetes-related renal complications: Insights on the impact of diabetic kidney disease on mortality
Guido Gembillo, Maria Federica Ricca, Domenico Santoro, Unit of Nephrology and Dialysis, AOU "G. Martino", University of Messina, Messina 98125, Sicilia, Italy
Author contributions: Gembillo G, Ricca MF and Santoro D contributed equally to the design and implementation of all the paper and to the writing of the manuscript; all the authors read and approved the final version of the manuscript.
Conflict-of-interest statement: We declare no conflict of interest.
Corresponding author: Guido Gembillo, MD, PhD, Consultant, Unit of Nephrology and Dialysis, AOU "G. Martino", University of Messina, Via Consolare Valeria n 1, Messina 98125, Sicilia, Italy. ggembillo@gmail.com
Received: April 14, 2025
Revised: May 30, 2025
Accepted: July 22, 2025
Published online: March 25, 2026
Processing time: 334 Days and 9 Hours
Revised: May 30, 2025
Accepted: July 22, 2025
Published online: March 25, 2026
Processing time: 334 Days and 9 Hours
Core Tip
Core Tip: Diabetic kidney disease (DKD) is a major microvascular consequence of diabetes mellitus and a major factor in the progression of chronic kidney disease worldwide. In addition to its contribution to end-stage kidney disease, DKD significantly associated with increased all-cause and cardiovascular mortality. Epidemiological studies have consistently shown that even the early stages of DKD, characterized by microalbuminuria or a slight reduction in estimated glomerular filtration rate, are associated with an increased risk of mortality. The results of the current literature highlight the significance of early detection and vigilant oversight and management of DKD patients.