Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Dec 25, 2025; 14(4): 111343
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.111343
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.111343
Concentration and predictive value of plasma neutrophil gelatinase-associated lipocalin in patients with acute pancreatitis and acute kidney injury
Kien Trung Nguyen, Division of Treatment, Military Medical Department, Ha Noi 114000, Viet Nam
Nhuong Huu Le, Department of Gastroenterology and Hematology, Military Hospital 354, Ha Noi 118000, Viet Nam
Thang Viet Le, Department of Nephrology and Hemodialysis, Military Hospital 103, Ha Noi 121000, Viet Nam
Dung Thai Pham, Center of Emergency, Critical Care Medicine and Clinical Toxicology, Military Hospital 103, Ha Noi 121000, Viet Nam
Tuan Anh Nguyen, Center of Emergency, Bach Mai Hospital, Ha Noi 115000, Viet Nam
Long Cong Nguyen, Center of Gastroenterology and Hepatology, Bach Mai Hospital, Ha Noi 115000, Viet Nam
Son Ngoc Do, Center for Critical Care Medicine, Bach Mai Hospital, Ha Noi 115000, Viet Nam
Author contributions: All authors were involved in the conceptualization of the manuscript and its development, execution, analysis of results, primary drafting, and critical revision, and have read and agreed to the published version.
Institutional review board statement: The study protocol was approved by the ethics committee of Bach Mai Hospital (No. 3094/BVBM-HDD/2021).
Informed consent statement: All the patients provided informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nhuong Huu Le, PhD, Department of Gastroenterology and Hema
Received: July 1, 2025
Revised: July 18, 2025
Accepted: October 30, 2025
Published online: December 25, 2025
Processing time: 178 Days and 19 Hours
Revised: July 18, 2025
Accepted: October 30, 2025
Published online: December 25, 2025
Processing time: 178 Days and 19 Hours
Core Tip
Core Tip: Severe acute pancreatitis (AP) is frequently associated with multiple complications, including acute kidney injury (AKI). In clinical practice, the early diagnosis of AKI remains challenging. This study provides evidence of the value of plasma neutrophil gelatinase-associated lipocalin in predicting the occurrence of AKI, assessing the severity of AP, and forecasting the need for continuous renal replacement therapy in patients with AP complicated by AKI. Additionally, we analyzed the correlation between plasma neutrophil gelatinase-associated lipocalin levels and clinical and paraclinical characteristics.