Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Dec 25, 2025; 14(4): 109099
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.109099
Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.109099
Donor-derived cell-free DNA and its utility in kidney transplantation: A myth or a reality
Muhammad Abdul Mabood Khalil, Nihal Mohammed Sadagah, Hinda Hassan Khideer Mahmood, Alfatih Abdalla Altom, Salem H Al-Qurashi, Center of Renal Diseases and Transplantation, King Fahad Armed Forces Hospital Jeddah, Jeddah 23311, Makkah al Mukarramah, Saudi Arabia
Jackson Tan, Department of Nephrology, RIPAS Hospital Brunei Darussalam, Bander Seri Begawan BA1712, Brunei Darussalam
Author contributions: Khalil MAM, Sadagah NM, Al-Qurashi SH, and Tan J planned and designed the outline of the manuscript; Khalil MAM wrote the manuscript; Sadagah NM, Mahmood HHK, Altom AA, Tan J, and Al-Qurashi SH helped in the literature search and supported in writing; all authors read and agreed to the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest in this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammad Abdul Mabood Khalil, FRCP, Center of Renal Diseases and Transplantation, King Fahad Armed Forces Hospital Jeddah, Al Kurnaysh Br Road, Al Andalus, Jeddah 23311, Makkah al Mukarramah, Saudi Arabia.
Received: April 29, 2025
Revised: June 9, 2025
Accepted: September 10, 2025
Published online: December 25, 2025
Processing time: 238 Days and 9.7 Hours
Revised: June 9, 2025
Accepted: September 10, 2025
Published online: December 25, 2025
Processing time: 238 Days and 9.7 Hours
Core Tip
Core Tip: Donor-derived cell-free DNA is a biomarker for detecting antibody-mediated rejection. It has a potential role for renal allograft surveillance, assessing the immune system reactivity, and monitoring response to rejection therapy. This minireview will focus on its clinical utilization, method of estimation, quantification, and will provide a way for its integration with clinical parameters and gene profiling for its best utility.