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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Sep 25, 2025; 14(3): 109400
Published online Sep 25, 2025. doi: 10.5527/wjn.v14.i3.109400
Published online Sep 25, 2025. doi: 10.5527/wjn.v14.i3.109400
Avacopan in the treatment of relapsing polychondritis with myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis: A case report
Jack Tang Nguyen, College of Medicine, University of Cincinnati, Cincinnati, OH 45220, United States
Manish Anand, Department of Internal Medicine, Division of Nephrology, University of Cincinnati Medical Center, Cincinnati, OH 45220, United States
Author contributions: Nguyen JT and Anand M were involved in the care of the patient; Nguyen JT and Anand M wrote the case report, have read, and approved the paper.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and any accompanying images. The patient has been assured that all personal identifiers have been removed to protect confidentiality.
Conflict-of-interest statement: All authors declare that there are no conflicts of interest related to this case report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jack Tang Nguyen, Doctorate Student, College of Medicine, University of Cincinnati, 3230 Eden Avenue, Cincinnati, OH 45220, United States.
Received: May 12, 2025
Revised: May 28, 2025
Accepted: July 10, 2025
Published online: September 25, 2025
Processing time: 131 Days and 6 Hours
Revised: May 28, 2025
Accepted: July 10, 2025
Published online: September 25, 2025
Processing time: 131 Days and 6 Hours
Core Tip
Core Tip: This case report presents a rare overlap of relapsing polychondritis and myeloperoxidase anti-neutrophil cytoplasmic antibody associated vasculitis, complicated by severe acute kidney injury. The patient demonstrated sustained renal improvement following treatment with Avacopan, a complement 5a receptor antagonist, after intolerance to rituximab. This case highlights the potential role of Avacopan in preserving renal function and achieving disease control in complex autoimmune syndromes, especially when conventional immunosuppressive regimens are contraindicated or poorly tolerated.