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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Sep 25, 2025; 14(3): 107736
Published online Sep 25, 2025. doi: 10.5527/wjn.v14.i3.107736
Published online Sep 25, 2025. doi: 10.5527/wjn.v14.i3.107736
Cardamom extract: An effective weapon in prevention of cardiorenal syndrome induced in rats by cisplatin and high-fat diet
Doha Mohamed, Ibrahim Hamed, Hoda B Mabrok, Department of Nutrition and Food Science, National Research Centre, Cairo 12622, Egypt
Author contributions: Mohamed D contributed to conceptualization and supervision; Mohamed D and Mabrok HB contributed to methodology; Mohamed D, Mabrok HB, and Hamed I contributed to data curation; all authors contributed to original draft writing, review and editing; All authors have read and agreed to the published version of the manuscript.
Supported by the National Research Centre, Egypt, No. 13050203.
Institutional animal care and use committee statement: This study was done as part of internal project No. 13050203 funded by the NRC. The project procedures were permitted by the Medical Research Ethics Committee, NRC (approval number 13050203) following the recommendations of the National Institutes of Health Guide for Care and Use of Laboratory Animals (Publication No. 85-23, revised 1985).
Conflict-of-interest statement: All authors declare no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data is available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Doha Mohamed, PhD, Professor, Department of Nutrition and Food Science, National Research Centre, 33 El Buhouth St, Dokki, Cairo 12622, Egypt.
Received: March 28, 2025
Revised: April 20, 2025
Accepted: June 10, 2025
Published online: September 25, 2025
Processing time: 173 Days and 10.2 Hours
Revised: April 20, 2025
Accepted: June 10, 2025
Published online: September 25, 2025
Processing time: 173 Days and 10.2 Hours
Core Tip
Core Tip: In this study, cardiorenal syndrome (CRS) was experimentally induced in rats using a high-fat diet and cisplatin. The protective effects of crude ethanol extract (CEE) of cardamom were evaluated through comprehensive biochemical analyses. The potential mechanistic role of CEE phenolics was explored via molecular docking with the Hippo signaling pathway. The findings suggest that CEE, as a phenolic-rich dietary supplement, may protect against CRS by reducing inflammation and oxidative stress, and by targeting components of the Hippo pathway.