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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Sep 25, 2025; 14(3): 107201
Published online Sep 25, 2025. doi: 10.5527/wjn.v14.i3.107201
Published online Sep 25, 2025. doi: 10.5527/wjn.v14.i3.107201
Management of earthquake-related acute renal injury
Fikri M Abu-Zidan, Department of Surgery, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain 17666, United Arab Emirates
Fikri M Abu-Zidan, Statistical and Research Methodology Consultant, The World Society of Emergency Surgery, Bologna, Via Cracovia 23, Italy
Kamal Idris, Department of Critical Care, The Intensive Care Unit, Burjeel Royal Hospital, Al-Ain 67006, United Arab Emirates
Arif Alper Cevik, Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain 17666, United Arab Emirates
Author contributions: Abu-Zidan FM supervised the project, did the literature search, retrieved the literature, critically read and wrote sections on the disaster and critical care management, organized the structure of the manuscript, and repeatedly edited the manuscript; Idris K critically read and wrote the sections on acute kidney injury and its management; Cevik AA critically read and wrote the section on the management of crush syndrome; all authors have contributed to the idea, and approved the last version of the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fikri M Abu-Zidan, MD, FACS, FRCS, PhD, Dip Applied Statistics, Professor of Disaster Medicine, Consultant of Statistics and Research Methodology, Department of Surgery, College of Medicine and Health Sciences, United Arab Emirates University, Sheik Khalifa Bin Zayed Street, Abu Dhabi, Al-Ain 17666, United Arab Emirates.
Received: March 17, 2025
Revised: April 13, 2025
Accepted: May 10, 2025
Published online: September 25, 2025
Processing time: 183 Days and 20.4 Hours
Revised: April 13, 2025
Accepted: May 10, 2025
Published online: September 25, 2025
Processing time: 183 Days and 20.4 Hours
Core Tip
Core Tip: The causes of earthquake-related acute kidney injury (AKI) include: (1) Prerenal include bleeding, dehydration, ischaemia-reperfusion injury, or cardiac depression; and (2) Renal include nephrotoxic effects of the uric acid and bilirubin, tubular casts obstructing the tubules, or intra-renal deposition of phosphorus and calcium. Pelvic fractures may cause urethral rupture with postrenal obstruction. The management principles of crush syndrome and AKI include: (1) Proper fluid therapy to maintain adequate urine output; (2) Preventing and treating hyperkalemia; and (3) Renal replacement therapy when indicated in cases of severe hyperkalemia, severe acidemia, volume overload, or severe uremia.