Meena P, Bhargava V, Singh K, sethi J, Prabhakar A, panda S. Cryptococcosis in kidney transplant recipients: Current understanding and practices. World J Nephrol 2023; 12(5): 120-131 [PMID: 38230297 DOI: 10.5527/wjn.v12.i5.120]
Corresponding Author of This Article
Priti Meena, MBBS, MD, DNB Nephrology, FASN, Assistant professor, Department of Nephrology, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India. pritimn@gmail.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Priti Meena, Sandip panda, Department of Nephrology, All India Institute of Medical Sciences, Bhubaneswar 751019, Odhisha, India
Vinant Bhargava, Department of Nephrology, Sir Ganga Ram Hospital New Delhi, New Delhi 110001, New Delhi, India
Kulwant Singh, Department of Nephrology, Ivy Hospital, Mohali Punjab, Mohali 160071, Punjab, India
Jasmine sethi, Department of Nephrology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, Punjab, India
Aniketh Prabhakar, Department of Nephrology, Consultant Nephrologist, Sigma Hospital, Mysore 570009, Karnataka, India
Author contributions: Meena P and Sethi J drafted the manuscript; Bhargava V conceptualized the idea and helped in writing; Singh K helped in reviewing and writing of the manuscript; Prabhakar A and Panda S edited the manuscipt.
Conflict-of-interest statement: Authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Priti Meena, MBBS, MD, DNB Nephrology, FASN, Assistant professor, Department of Nephrology, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India. pritimn@gmail.com
Received: August 3, 2023 Peer-review started: August 3, 2023 First decision: August 24, 2023 Revised: October 15, 2023 Accepted: November 2, 2023 Article in press: November 2, 2023 Published online: December 25, 2023 Processing time: 140 Days and 22.6 Hours
Core Tip
Core Tip: Cryptococcosis is the third most common invasive fungal infection in solid organ transplant recipients. As an opportunistic infection, it poses substantial morbidity and mortality in kidney transplant recipients. Mortality rates for cryptococcosis range from 10% to 25%. In immunocompromised patients, especially in cryptococcus-endemic areas, cryptococcosis must be suspected and diagnosed with a low threshold. Compared to India ink and fungal cultures, tests for the cryptococcal antigen detection in cerebrospinal fluid or plasma test are more sensitive and specific. The management of cryptococcosis poses considerable difficulties, mostly done with reduction or optimization of immunosuppression in addition to lipid formulations of amphotericin B and fluconazole.
