Kapoor H, Kapoor D. Left ventricular diastolic dysfunction in chronic kidney disease and anaesthesia implications. World J Nephrol 2025; 14(4): 111297 [DOI: 10.5527/wjn.v14.i4.111297]
Corresponding Author of This Article
Hemlata Kapoor, MD, Consultant, Department of Anaesthesiology and Intensive Care, Kokilaben Dhirubhai Ambani Hospital, 4 Bungalows Andheri W, Mumbai 400053, Mahārāshtra, India. h_sarinkapoor@hotmail.co.uk
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 25, 2025 (publication date) through Dec 23, 2025
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World Journal of Nephrology
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2220-6124
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Kapoor H, Kapoor D. Left ventricular diastolic dysfunction in chronic kidney disease and anaesthesia implications. World J Nephrol 2025; 14(4): 111297 [DOI: 10.5527/wjn.v14.i4.111297]
World J Nephrol. Dec 25, 2025; 14(4): 111297 Published online Dec 25, 2025. doi: 10.5527/wjn.v14.i4.111297
Left ventricular diastolic dysfunction in chronic kidney disease and anaesthesia implications
Hemlata Kapoor, Dheeraj Kapoor
Hemlata Kapoor, Department of Anaesthesiology and Intensive Care, Kokilaben Dhirubhai Ambani Hospital, Mumbai 400053, Mahārāshtra, India
Dheeraj Kapoor, Deopartment of Endocrinology, Kokilaben Dhirubhai Ambani Hopsital and Research Centre, Mumbai 400053, India
Co-first authors: Hemlata Kapoor and Dheeraj Kapoor.
Author contributions: Kapoor H and Kapoor D designed the study, researched various articles on the subject and prepared the manuscript.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hemlata Kapoor, MD, Consultant, Department of Anaesthesiology and Intensive Care, Kokilaben Dhirubhai Ambani Hospital, 4 Bungalows Andheri W, Mumbai 400053, Mahārāshtra, India. h_sarinkapoor@hotmail.co.uk
Received: June 27, 2025 Revised: July 29, 2025 Accepted: October 28, 2025 Published online: December 25, 2025 Processing time: 179 Days and 11.6 Hours
Abstract
Left ventricular diastolic dysfunction is frequently noticed in patients with chronic kidney disease. Echocardiography is used to determine the presence and severity of diastolic dysfunction. In left ventricular diastolic dysfunction the ventricular diastolic distensibility, filling or relaxation is abnormal; however, the left ventricular ejection fraction may be normal or decreased. In heart failure with preserved ejection fraction, the patients have symptomatic pulmonary congestion even though the systolic ejection fraction is more than 50%. This condition is commonly associated with ventricular diastolic dysfunction. Increased incidence of major adverse cardiovascular events has been reported in surgical patients having grade III diastolic dysfunction. Peri-operatively haemodynamic instability and fluid overload in this set of patients is known to generate pulmonary oedema.
Core Tip: The extent of diastolic dysfunction in renal failure patients is increasingly gaining interest. Its implications on progress of chronic kidney disease and vice versa are known as cardiorenal syndrome. These patients present with heart failure inspite of adequate ejection fraction. These patients sometimes have pulmonary oedema during weaning of from ventilator. Various pharmcotherapeutic agents have been found useful in preserving contractility of heart.
