Role of soluble human leukocyte antigen-G in virus-associated cancers: A focused minireview

doi:10.5501/wjv.v15.i2.120048

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Virol. Jun 25, 2026; 15(2): 120048
Published online Jun 25, 2026. doi: 10.5501/wjv.v15.i2.120048

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Figure 1 Soluble human leukocyte antigen-G-mediated immune evasion in virus-associated cancers. Solid lines indicate experimentally demonstrated mechanisms, whereas dashed lines represent putative or hypothesized pathways. sHLA-G: Soluble human leukocyte antigen-G; HPV: Human papillomavirus; HCV: Hepatitis C virus; HBV: Hepatitis B virus; ILT2: Immunoglobulin-like transcript 2; ILT4: Immunoglobulin-like transcript 4; NK cell: Natural killer cell; CD8⁺ T cell: Cytotoxic T lymphocyte; IL-10: Interleukin-10; IFN-α: Interferon alpha; IFN-β: Interferon beta; α1, α2, α3: Alpha-1, alpha-2, and alpha-3 extracellular domains of human leukocyte antigen-G; β2m: Β₂-microglobulin; TME: Tumor microenvironment.

Citation: Bouayad A. Role of soluble human leukocyte antigen-G in virus-associated cancers: A focused minireview. World J Virol 2026; 15(2): 120048
URL: https://www.wjgnet.com/2220-3249/full/v15/i2/120048.htm
DOI: https://dx.doi.org/10.5501/wjv.v15.i2.120048

Bouayad A. Role of soluble human leukocyte antigen-G in virus-associated cancers: A focused minireview. World J Virol 2026; 15(2): 120048 [DOI: 10.5501/wjv.v15.i2.120048]

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