Role of soluble human leukocyte antigen-G in virus-associated cancers: A focused minireview

doi:10.5501/wjv.v15.i2.120048

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 2

This Article

(7)

(8)

(0)

(4)

(79)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Virology

ISSN

2220-3249

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Virol. Jun 25, 2026; 15(2): 120048
Published online Jun 25, 2026. doi: 10.5501/wjv.v15.i2.120048

Role of soluble human leukocyte antigen-G in virus-associated cancers: A focused minireview

Abdellatif Bouayad

Abdellatif Bouayad, Department of Immunology, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda 4867, Oriental, Morocco

Author contributions: Bouayad A wrote, designed, and approved the minireview manuscript.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Corresponding author: Abdellatif Bouayad, MD, Associate Professor, Department of Immunology, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Hay al Hikma, Oujda 4867, Oriental, Morocco. abdellatifbouayad@hotmail.fr

Received: February 13, 2026
Revised: March 8, 2026
Accepted: April 14, 2026
Published online: June 25, 2026
Processing time: 125 Days and 16.9 Hours

Core Tip

Core Tip: Increased soluble human leukocyte antigen-G (sHLA-G) levels are consistently associated with poor prognosis in hepatitis C virus/hepatitis B virus -related hepatocellular carcinoma and human papillomavirus-driven cervical cancer, underscoring its potential as a diagnostic and prognostic biomarker. High-risk human papillomavirus oncoproteins (E6 and E7) and hepatitis C virus proteins (core protein and nonstructural protein 3) may contribute to increased sHLA-G levels through cytokine-mediated immunosuppressive signalling pathways. The mechanisms by which sHLA-G-immunoglobulin-like transcript 2/immunoglobulin-like transcript 4 interactions modulate immune suppression in these virus-driven cancers remain incompletely understood. sHLA-G isoforms are primarily detected in plasma and other biological fluids using sandwich enzyme-linked immunosorbent assays, providing a reliable method for both clinical and research applications.