Collazos J, Valle-Garay E, Suárez-Zarracina T, Montes AH, Cartón JA, Asensi V. Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients. World J Virol 2017; 6(2): 36-45 [PMID: 28573088 DOI: 10.5501/wjv.v6.i2.36]
Corresponding Author of This Article
Dr. Julio Collazos, Infectious Diseases Unit, Hospital de Galdácano, Bº Labeaga s/n, 48960 Vizcaya, Spain. med003033@gmail.com
Research Domain of This Article
Allergy
Article-Type of This Article
Observational Study
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Collazos J, Valle-Garay E, Suárez-Zarracina T, Montes AH, Cartón JA, Asensi V. Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients. World J Virol 2017; 6(2): 36-45 [PMID: 28573088 DOI: 10.5501/wjv.v6.i2.36]
World J Virol. May 12, 2017; 6(2): 36-45 Published online May 12, 2017. doi: 10.5501/wjv.v6.i2.36
Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients
Julio Collazos, Eulalia Valle-Garay, Tomás Suárez-Zarracina, Angel-Hugo Montes, José A Cartón, Víctor Asensi
Julio Collazos, Infectious Diseases, Hospital de Galdácano, 48960 Vizcaya, Spain
Eulalia Valle-Garay, Angel-Hugo Montes, Biochemistry and Molecular Biology, Hospital Universitario Central de Asturias, Oviedo University School of Medicine, 33006 Oviedo, Spain
Tomás Suárez-Zarracina, José A Cartón, Víctor Asensi, Infectious Diseases, Hospital Universitario Central de Asturias, Oviedo University School of Medicine, 33006 Oviedo, Spain
Author contributions: Collazos J, Suárez-Zarracina T, Cartón JA and Asensi V designed the study and contributed to the data acquisition and selection; Valle-Garay E and Montes AH performed the laboratory determinations and genotypic studies; Collazos J analyzed the data; Collazos J and Asensi V wrote the draft of the initial manuscript; Suárez-Zarracina T, Valle-Garay E, Montes AH and Cartón JA revised the article critically for important intellectual content.
Supported by the Oviedo University research grants, Nos. UNIOV-12-MA-03 and SV-PA-13-ECOEMP-57.
Institutional review board statement: The study was approved by the Principado de Asturias Research Ethic Committee.
Informed consent statement: Given the nature of the study, no formal written approval was necessary, according to our institution’s regulations, being enough a verbal informed consent, which was obtained from all patients.
Conflict-of-interest statement: There is no conflict of interest related to this paper.
Data sharing statement: No additional data are available.
Correspondence to: Dr. Julio Collazos, Infectious Diseases Unit, Hospital de Galdácano, Bº Labeaga s/n, 48960 Vizcaya, Spain. med003033@gmail.com
Telephone: +34-94-6032860 Fax: +34-94-6032867
Received: October 30, 2016 Peer-review started: November 3, 2016 First decision: December 1, 2016 Revised: December 20, 2016 Accepted: February 8, 2017 Article in press: February 13, 2017 Published online: May 12, 2017 Processing time: 194 Days and 2.9 Hours
Core Tip
Core tip: The role of matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs) in the development of liver fibrosis is uncertain. We determined some single nucleotide polymorphisms (SNPs), as well as the serum levels of diverse MMPs and TIMPs, in non-alcoholic, human immunodeficiency virus-infected patients with/out hepatitis C virus coinfection, to evaluate their possible relationship with liver fibrosis as assessed by transient elastometry. MMP-2 was independently associated with significant fibrosis. Likewise, MMP-2, TIMP-2 and MMP-9 were independent predictors of transient elastometry values and of other non-invasive tests of fibrosis. No SNP was significantly associated with liver fibrosis. Our findings support the value of these markers in the evaluation of fibrosis.
