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World Journal of Virology
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2220-3249
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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Virol. Jun 25, 2026; 15(2): 119515
Published online Jun 25, 2026. doi: 10.5501/wjv.v15.i2.119515
Understanding machupo virus: A neglected arenavirus with global health importance
Praveen Kumar Uppala, Sita Kumari Karanam, Naga Vishnu Kandra, Sandhya Edhi
Praveen Kumar Uppala, Department of Pharmacology, Maharajah’s College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Sita Kumari Karanam, Department of Biotechnology, Maharajah’s College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Naga Vishnu Kandra, Department of Radiodiagnosis, Santhiram Medical College and General Hospital, Nandyal 518501, Andhra Pradesh, India
Sandhya Edhi, Department of Pharmacognosy, Andhra University College of Pharmaceutical Sciences, Visakhapatnam 530003, Andhra Pradesh, India
Author contributions: Uppala PK contributed to concept, design, drafting manuscript; Karanam SK contributed to final revision of manuscript; Kandra NV contributed to literature search; Edhi S contributed to literature search, design.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Praveen Kumar Uppala, Assistant Professor, Researcher, Department of Pharmacology, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, India. praveen.chintu32@gmail.com
Received: February 2, 2026
Revised: February 22, 2026
Accepted: April 10, 2026
Published online: June 25, 2026
Processing time: 138 Days and 22.6 Hours
Core Tip

Core Tip: Machupo virus, the etiological agent of Bolivian hemorrhagic fever, remains a neglected yet highly lethal arenavirus with significant biosafety and outbreak potential. This review integrates current knowledge on viral biology, transmission ecology, pathogenesis, diagnostics, and emerging countermeasures including monoclonal antibodies, antivirals, and next-generation vaccines. Strengthening one health surveillance and global research collaboration is essential to mitigate future spillover risks and improve preparedness against new world arenaviruses.
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