Letter to the Editor: Dengue virus as an underrecognized cause of encephalitis in tropical Asia - Bridging diagnostic and surveillance gaps

doi:10.5501/wjv.v15.i2.118082

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Virol. Jun 25, 2026; 15(2): 118082
Published online Jun 25, 2026. doi: 10.5501/wjv.v15.i2.118082

Letter to the Editor: Dengue virus as an underrecognized cause of encephalitis in tropical Asia - Bridging diagnostic and surveillance gaps

Alok Kumar, Devlina Ghosh

Alok Kumar, Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India

Devlina Ghosh, Department of Biochemistry, Saraswati Dental College and Hospital, Lucknow 226028, Uttar Pradesh, India

Author contributions: Kumar A conceived the study, developed the overall concept and manuscript framework, and contributed substantially to writing, critical discussion, editing, and figure design; Ghosh D contributed to the drafting and critical revision of the manuscript. All authors reviewed and approved the final submitted version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Alok Kumar, PhD, Additional Professor, Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India. dralokkumar03@gmail.com

Received: December 23, 2025
Revised: February 1, 2026
Accepted: March 5, 2026
Published online: June 25, 2026
Processing time: 177 Days and 16.4 Hours

Core Tip

Core Tip: Dengue virus is an under-recognized but clinically relevant cause of encephalitis in tropical Asia, where acute encephalitis syndrome remains etiologically heterogeneous. Emerging evidence of dengue virus serotype 3 neuroinvasion highlights diagnostic gaps arising from overlapping clinical features and limitations of conventional assays. Incorporating dengue testing within integrated, multi-pathogen diagnostic frameworks - combining molecular, serological, and advanced platforms such as metagenomic next-generation sequencing - can improve etiological attribution, surveillance accuracy, and patient management.