Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions

doi:10.5501/wjv.v13.i1.90384

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Mar 25, 2024 (publication date) through Dec 28, 2024

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Virol. Mar 25, 2024; 13(1): 90384
Published online Mar 25, 2024. doi: 10.5501/wjv.v13.i1.90384

Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions

M Victoria Delpino, Jorge Quarleri

M Victoria Delpino, Jorge Quarleri, Instituto de Investigaciones Biomédicas en Retrovirus y Sida, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires 1121, Argentina

Author contributions: Quarleri J and Delpino MV contributed equally to this work. Both authors have read and approved the final manuscript.

Conflict-of-interest statement: All the authors disclose no financial conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: M Victoria Delpino, PhD, Research Scientist, Instituto de Investi-gaciones Biomédicas en Retrovirus y Sida, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Paraguay 2155 Piso 11, Buenos Aires 1121, Argentina. mdelpino@ffyb.uba.ar

Received: December 1, 2023
Peer-review started: December 1, 2023
First decision: December 7, 2023
Revised: December 7, 2023
Accepted: January 5, 2024
Article in press: January 5, 2024
Published online: March 25, 2024
Processing time: 100 Days and 19.4 Hours

Core Tip

Core Tip: Hepatitis B virus (HBV) infection poses a global health concern without a definitive cure. This study delves into the complex interplay between lipid metabolism and HBV replication. It reveals that heightened lipid metabolism may exert an inhibitory effect on HBV replication. Specifically, increased fatty acids lead to the accumulation of lipid droplets and the upregulation of perilipin 2 in hepatocytes. This, in turn, inhibits autophagy and subsequently hinders HBV replication.