Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Mar 25, 2024; 13(1): 89469
Published online Mar 25, 2024. doi: 10.5501/wjv.v13.i1.89469
Global trends in hepatitis C-related hepatocellular carcinoma mortality: A public database analysis (1999-2019)
Hassam Ali, Fnu Vikash, Vishali Moond, Fatima Khalid, Abdur Rehman Jamil, Dushyant Singh Dahiya, Amir Humza Sohail, Manesh Kumar Gangwani, Pratik Patel, Sanjaya K Satapathy
Hassam Ali, Department of Internal Medicine/Gastroenterology, East Carolina University Brody School of Medicine, Greenville, NC 27834, United States
Fnu Vikash, Department of Internal Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, United States
Vishali Moond, Department of Internal Medicine, Saint Peter's University Hospital/Robert Wood Johnson Medical School, New Brunswick, NJ 08901, United States
Fatima Khalid, Department of Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur 63100, Punjab, Pakistan
Abdur Rehman Jamil, Department of Internal Medicine, Samaritan Medical Centre, Watertown, MA 13601, United States
Dushyant Singh Dahiya, Division of Gastroenterology, Hepatology & Motility, The University of Kansas School of Medicine, Kansas City, KS 66160, United States
Amir Humza Sohail, Department of Surgery, New York University Winthrop Hospital, New York, Mineloa, NY 11501, United States
Manesh Kumar Gangwani, Department of Internal Medicine, The University of Toledo, Toledo, OH 43606, United States
Pratik Patel, Department of Gastroenterology, Mather Hospital/Hofstra University Zucker School of Medicine, NY 11777, United States
Sanjaya K Satapathy, Division of Hepatology, Department of Medicine, North Shore University Hospital, Manhasset, NY 11030, United States
Author contributions: Author Contributions: Ali H, Sohail AH, Dahiya DS, and Vikash F were responsible for the conceptualization, methodology, software development, data curation, validation, and drafting the original manuscript; Ali H, Dahiya DS, Sohail AH, Khalid F, Moond V, and Gangwani MK contributed to the critical review and editing of the manuscript and took on roles in project administration; Jamil AR, Patel P, and Satapathy SK were involved in reviewing and editing the article and provided supervision throughout the project.
Institutional review board statement: The present study did not require institutional review board oversight because Global Burden of Disease Study 2019 database is de-identified and freely accessible. It does not identify hospitals, health care providers, or patients.
Informed consent statement: Participants were not required to give informed consent to this retrospective study since the analysis of baseline characteristics used publicly available anonymized clinical data. Please contact me for any queries.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: The data used in this study is publicly available at Global Burden of Disease Study 2019 (GBD 2019) (https://ghdx.healthdata.org/gbd-2019).
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hassam Ali, MD, Academic Fellow, Academic Research, Department of Internal Medicine/Gastroenterology, East Carolina University Brody School of Medicine, 2100 Statonsburg Rd, Greenville, NC 27834, United States. alih20@ecu.edu
Received: November 2, 2023
Peer-review started: November 2, 2023
First decision: December 19, 2023
Revised: December 19, 2023
Accepted: January 18, 2024
Article in press: January 18, 2024
Published online: March 25, 2024
Processing time: 130 Days and 13.1 Hours
Core Tip

Core Tip: Hepatitis C virus (HCV) remains a crucial precursor for hepatocellular carcinoma (HCC), accounting for a significant proportion of HCC-related mortalities. Our study focused on trends from 1999 to 2019 and offers an extensive temporal analysis on the mortality rates in patients with HCV-related HCC. The data highlighted that despite advances in antiviral treatments for HCV, the mortality rates in HCC have not seen a corresponding decline. We also identified noticeable trends relating to gender, providing insights into demographic groups that are disproportionately affected. This study emphasizes the need for targeted interventions to reduce mortality rates in HCV-associated HCC, despite advancements in HCV treatment.