Published online Sep 25, 2022. doi: 10.5501/wjv.v11.i5.300
Peer-review started: July 29, 2022
First decision: August 22, 2022
Revised: August 22, 2022
Accepted: September 1, 2022
Article in press: September 1, 2022
Published online: September 25, 2022
Processing time: 56 Days and 21.5 Hours
Core Tip: Vitamin C has several biochemical effects including anti-oxidant, anti-inflammatory, immuno-modulatory, and anti-viral properties which could make it a possible low-risk, add on to the current therapeutic options for managing coronavirus disease 2019 (COVID-19) patients. As it is a water-soluble vitamin, even high doses have been shown to be safe and only rarely, complications have been reported. In the last couple of years, many case series, observational studies and even randomised control trials have been conducted to evaluate the role of vitamin C in COVID-19, but have shown conflicting results. Hence, as per the current clinical evidence, the role of vitamin C remains ambiguous and it cannot be recommended as a part of routine therapeutic regimen for managing COVID-19 patients.