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World J Virology. Aug 12, 2015; 4(3): 295-302
Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.295
Diagnostic assays developed for the control of foot-and-mouth disease in India
Gaurav Kumar Sharma, Sonalika Mahajan, Rakesh Matura, Saravanan Subramaniam, Rajeev Ranjan, Jitendra Biswal, Manoranjan Rout, Jajati Keshari Mohapatra, Bana Bihari Dash, Aniket Sanyal, Bramhadev Pattnaik
Gaurav Kumar Sharma, Sonalika Mahajan, Rakesh Matura, Saravanan Subramaniam, Rajeev Ranjan, Jitendra Biswal, Manoranjan Rout, Jajati Keshari Mohapatra, Bana Bihari Dash, Aniket Sanyal, Bramhadev Pattnaik, Project Directorate on Foot and Mouth Disease, Indian Council of Agricultural Research, Mukteswar, Uttarakhand 263138, India
Author contributions: Sharma GK designed the scope of the minireview and wrote the paper; Mahajan S and Matura R reviewed the literature and compiled the data; Saravanan S, Ranjan R and Biswal J analyzed the FMD virus diagnosis data; Sharma GK, Mahajan S and Dash BB analyzed the herd immunity data; Rout M and Mohapatra JK analyzed the FMD sero-surveillance data; Sharma GK and Pattnaik B compiled and revised the manuscript; Sanyal A compiled the molecular diagnosis of FMD data and revised the manuscript.
Conflict-of-interest statement: The authors declare no conflict-of-interest in this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Bramhadev Pattnaik, MVSc, PhD, Project Director, Project Directorate on Foot and Mouth Disease, Indian Council of Agricultural Research, IVRI Campus, Mukteswar, Uttarakhand 263138, India. pattnaikb@gmail.com
Telephone: +91-5942-286004 Fax: +91-5942-286307
Received: November 6, 2014
Peer-review started: November 10, 2014
First decision: January 20, 2015
Revised: February 13, 2015
Accepted: May 5, 2015
Article in press: May 6, 2015
Published online: August 12, 2015
Processing time: 279 Days and 18.3 Hours
Abstract

Foot-and-mouth disease (FMD) is a highly contagious and economically devastating disease of livestock, primarily affecting cattle, buffalo and pigs. FMD virus serotypes O, A and Asia1 are prevalent in India and systematic efforts are on to control and eventually eradicate the disease from the country. FMD epidemiology is complex due to factors like co-circulation, extinction, emergence and re-emergence of genotypes/lineages within the three serotypes, animal movement, diverse farm practices and large number of susceptible livestock in the country. Systematic vaccination, prompt diagnosis, strict biosecurity measures, and regular monitoring of vaccinal immunity and surveillance of virus circulation are indispensible features for the effective implementation of the control measures. Availability of suitable companion diagnostic tests is very important in this endeavour. In this review, the diagnostic assays developed and validated in India and their contribution in FMD control programme is presented.

Keywords: Foot-and-mouth disease; Diagnosis; Sero-surveillance; Sero-monitoring; Multiplex polymerase chain reaction; Real-time polymerase chain reaction; Lineage differentiating polymerase chain reaction

Core tip: To inform scientific community, this short review summarizes existing foot-and-mouth disease diagnostics developed in the recent past and used in India. Immediate and future requirements in the diagnostics are highlighted.