Combined prevention and treatment measures are essential to control nosocomial infections during the COVID-19 pandemic

Abstract

Severe acute respiratory syndrome coronavirus-2 is a highly contagious positive-sense, single-stranded RNA virus that has rapidly spread worldwide. As of December 17, 2023, 772838745 confirmed cases including 6988679 deaths have been reported globally. This virus primarily spreads through droplets, airborne transmission, and direct contact. Hospitals harbor a substantial number of confirmed coronavirus disease 2019 (COVID-19) patients and asymptomatic carriers, accompanied by high population density and a larger susceptible population. These factors serve as potential triggers for nosocomial infections, posing a threat during the COVID-19 pandemic. Nosocomial infections occur to varying degrees across different countries worldwide, emphasizing the urgent need for a practical approach to prevent and control the intra-hospital spread of COVID-19. This study primarily concentrated on a novel strategy combining preventive measures with treatment for combating COVID-19 nosocomial infections. It suggests preventive methods, such as vaccination, disinfection, and training of heathcare personnel to curb viral infections. Additionally, it explored therapeutic strategies targeting cellular inflammatory factors and certain new medications for COVID-19 patients. These methods hold promise in rapidly and effectively preventing and controlling nosocomial infections during the COVID-19 pandemic and provide a reliable reference for adopting preventive measures in the future pandemic.

Keywords: COVID-19; SARS-CoV-2; Nosocomial infection; Prevention; Treatment

Core Tip: During the coronavirus disease 2019 (COVID-19) pandemic, nosocomial infections severely challenged healthcare professionals worldwide. Mitigating intra-hospital diseases remains a crucial task for healthcare practitioners. This study concentrated on pivotal strategies for preventing and controlling COVID-19 infections within medical facilities. It advocated viral infection prevention through vaccination, disinfection, and the training of heathcare personnel. Simultaneously, it explored therapeutic strategies involving cellular inflammatory factors and certain new medications tailored for COVID-19 patients. These methods could prevent and control intra-hospital infections swiftly and effectively during the COVID-19 outbreak.