Peer-review started: September 13, 2022
First decision: September 29, 2022
Revised: October 14, 2022
Accepted: January 3, 2023
Article in press: January 3, 2023
Published online: March 25, 2023
Processing time: 189 Days and 1 Hours
The coronavirus disease 2019 (COVID-19) disease was first detected in December 2019 in Wuhan, China. This disease is currently one of the most important global health problems. The novel coronavirus COVID-19 is a respiratory illness, that has caused a deadly pandemic that is spreading rapidly around the world. It is not only a respiratory system virus that causes severe lung disease, but also a systemic disease agent that can affect all systems. People with COVID-19 disease usually have respiratory signs, however, the liver disorder is not an uncommon presentation. In addition, many studies around the world have revealed that the liver is injured to various degrees in patients with severe acute respiratory syndrome coronavirus 2 disease. This review mainly focuses on the impact of COVID-19 on Liver Injury at various ages.
Core Tip: Studies have shown that neonates have rare evidence of liver damage, and in terms of age, they show the least amount of liver damage in the face of coronavirus disease 2019 (COVID-19) among affected people. Also, many studies reported different patterns of liver damage among children with COVID-19 much less than in adults, which is probably related to differences in their innate immune system and adaptation. The highest rate of liver damage is in adult patients and aspartate aminotransferase levels had the highest relevance with mortality compared to other indices reflecting liver injury.