Implementation of a pediatric kidney transplantation program in Uzbekistan: Feasibility and early outcomes

Table 1 Patient baseline demographic and perioperative characteristics, n (%)

Variables	Value (n = 20)
Age, month, median (range)	167 (87-207)
Sex
Male	12 (60)
Female	8 (40)
Indications for transplant
CAKUT	8 (40)
Tubulointerstitial nephritis	5 (25)
Glomerulonephritis	5 (25)
Toxic kidney injury	1 (5)
Russell-Silver syndrome nephropathy	1 (5)
AH before transplantation	12 (60)
Dialysis before transplantation	17 (85)
Time on dialysis before transplantation, month, median (range)	5 (2-66)
Urea before transplantation, mmol/L, median (range)	21 (10.9-35)
Creatinine before transplantation, µmol/L, median (range)	503.5 (211-1230)
Pre-existing antibodies	6 (30)
Operation time, minutes, median (range)	237.5 (195-380)
Side of graft placement
Right	18 (90)
Left	2 (10)
Native kidneys nephrectomy	2 (10)
Cold ischemia time, minutes, median (range)	15 (10-138)
Warm ischemia time, minutes, median (range)	35 (18-40)
Kidney graft immediate function after reperfusion	20 (100)
Creatinine 1 p/o day, µmol/L, median (range)	198 (24-695)
Creatinine 3 p/o day, µmol/L, median (range)	57(19-479)
Creatinine 5 p/o day, µmol/L, median (range)	74.5 (21-166)
Creatinine 7 p/o day, µmol/L, median (range)	54 (22-188)
Urea 1 p/o day, mmol/L, median (range)	13.5 (2.9-23.3)
Urea 3 p/o day, mmol/L, median (range)	6.3 (1.6-13.4)
Urea 5 p/o day, mmol/L, median (range)	5.7 (1.9-17.2)
Urea 7 p/o day, mmol/L, median (range)	5.6 (2-10.2)
Diuresis 1 p/o day, ml, median (range)	5080 (3500-13000)
Diuresis 3 p/o day, ml, median (range)	5665 (3240-9770)
Diuresis 5 p/o day, ml, median (range)	3855 (2400-6550)
Diuresis 7 p/o day, ml, median (range)	3000 (2400-7800)
Early complications, Clavien–Dindo
Grade 2 (Rejection)	1 (5)
Grade 4a (Hypotension and respiratory insufficiency)	1 (5)
CCI for early complications, median	0 (0-42.4)
Late complications, Clavien–Dindo
Grade 2 (Rejection)	1 (5)
Grade 3b (Rejection, graft nephrectomy)	1 (5)
Grade 5 (Hemorrhagic stroke)	1 (5)
CCI for early complications, median	0 (0-100)
LOS, days, median (range)	11 (7-15)
In-hospital survival	20 (100)
Overall survival	19 (95)
Cause of death, n
Hemorrhagic stroke	1
Graft survival	18 (90)
Cause of graft loss
Rejection	2
Follow-up period, month, median (range)	17 (2-24)

CAKUT: Congenital anomalies of the kidney and urinary tract; AH: Arterial hypertension; p/o day: Postoperative day; CCI: Comprehensive complication index; LOS: Length of stay.

Table 2 Donor clinical characteristics and outcomes, n (%)

Variables	Value (n = 20)
Age, years, median (range)	38 (31-50)
Sex
Male	7 (35)
Female	13 (65)
BMI, kg/m2, median (range)	27.4
Operation time, minutes, median (range)
Open	182.5 (110-260)
Laparoscopic with manual assistance	198.5 (190-230)
Complications, Clavien–Dindo
Grade 1
Wound seroma	1 (5)
Median CCI	0 (0-8.7)
LOS, days	7 (4-12)

BMI: Body mass index; LOS: Length of stay; CCI: Comprehensive complication index.