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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2025; 15(4): 107728
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.107728
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.107728
Implementation of a pediatric kidney transplantation program in Uzbekistan: Feasibility and early outcomes
Konstantin Semash, Timur Dzhanbekov, Qosimjon Umarov, Jurabek Dustmurodov, Department of Minimally Invasive Pediatric Surgery and Transplantation, National Children's Medical Center, Tashkent 100171, Toshkent, Uzbekistan
Akrom Akhmedov, Department of Vascular Surgery and Kidney Transplantation, V. Vakhidov Republican Specialized Scientific and Practical Medical Center of Surgery, Tashkent 100115, Toshkent, Uzbekistan
Author contributions: Semash K oversaw and coordinated all administrative aspects, including study planning, logistics, and compliance with ethical and regulatory standards; Semash K provided overall clinical and methodological supervision throughout the study, ensuring accuracy, scientific validity, and adherence to transplant protocols; Semash K developed the original concept of implementing the pediatric kidney transplantation program and formulated the overall goals and objectives of the study; Semash K, Akhmedov A, Dzhanvekov T, and Umarov Q established the clinical and research methodology, including donor selection criteria, surgical protocols, immunological assessments, and postoperative management guidelines; Semash K conducted statistical analysis, including interpretation of perioperative outcomes, complication rates, graft function parameters, and survival analysis; Dzhanbekov T, Semash K, and Akhmedov A provided essential resources, including surgical instruments, medical supplies, equipment for diagnostics and postoperative care, and access to laboratory and imaging facilities; Semash K, Dzhanbekov T, Umarov Q, and Dustmurodov J collected, organized, verified, and maintained data records from clinical observations, patient follow-up, laboratory results, and imaging studies; Semash K prepared and organized all visual data, including creating and reviewing figures, diagrams, and tables to clearly represent clinical outcomes and surgical techniques; Semash K drafted the initial manuscript, structured the text, and compiled data into a coherent and scientifically rigorous narrative; Semash K, Akhmedov A, Dzhanbekov T, Umarov Q, and Dustmurodov J critically reviewed the manuscript, provided substantial intellectual input, revised the content, and approved the final version for submission.
Institutional review board statement: The study «Implementation of a Pediatric Kidney Transplantation Program in Uzbekistan: Feasibility and Early Outcomes» was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. Ethical approval was obtained from the Institutional Review Board (IRB) of the National Children’s Medical Center, protocol number #738-77-2025, dated March 05, 2025. Written informed consent was obtained from all participants or their legal guardians, ensuring the confidentiality and anonymity of patient data throughout the research process.
Informed consent statement: The study was approved by the Institutional Review Board of the National Children’s Medical Center, Tashkent, Uzbekistan (IRB statement #738-77-2025). The patients provided written consent allowing the use of medical data for scientific research while ensuring the anonymity of the patients.
Conflict-of-interest statement: All the authors declare no actual or potential conflicts of interest.
Data sharing statement:
The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request. All requests for data should clearly specify the purpose, methodology, and scope of the intended research. Data will be provided in an anonymized format to ensure patient confidentiality and compliance with institutional ethical guidelines.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Konstantin Semash, MD, PhD, Department of Minimally Invasive Pediatric Surgery and Transplantation, National Children's Medical Center, Parkent Street 294, Tashkent 100171, Toshkent, Uzbekistan. doctorsemash@gmail.com
Received: April 1, 2025
Revised: April 14, 2025
Accepted: May 18, 2025
Published online: December 18, 2025
Processing time: 236 Days and 11.2 Hours
Revised: April 14, 2025
Accepted: May 18, 2025
Published online: December 18, 2025
Processing time: 236 Days and 11.2 Hours
Core Tip
Core Tip: This is the first report on the establishment of a pediatric kidney transplantation program from living-related donors in Uzbekistan. We present detailed surgical techniques, immunological screening protocols, and early clinical outcomes based on the first 20 transplantations. All recipients demonstrated immediate graft function without delayed graft function. At 24 months, patient survival was 95% and graft survival was 90%. This study demonstrates the feasibility, safety, and effectiveness of introducing pediatric kidney transplantation in a limited-resource setting, and may serve as a practical model for developing similar programs in other low- and middle-income countries.