Lesson learnt from 60 years of liver transplantation: Advancements, challenges, and future directions

Table 1 A list of the most commonly prescribed immunosuppressive drugs in organ transplantation, adopted from Anghel et al[170]

Immunosuppression class	Drugs/therapies	Mechanism of action
Antimetabolites	Mycophenolate mofetil	Inhibition of de novo purine synthesis in lymphocytes
Biologic agents	Polyclonal antibodies (ATGAM, Thymoglobulin)	Lysis of lymphocytes
Calcineurin inhibitors	Cyclosporine A Tacrolimus	Inhibitors of an intracellular phosphate required for interleukin-2 production in the T lymphocytes
Corticosteroids	Methylprednisolone; Prednisone	Regulators of gene expression
Non-calcineurin inhibitors	Sirolimus; Everolimus	Inhibitors of mammalian target of target of rapamycin activation in lymphocytes, resulting in cycle cell arrest