Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Mar 18, 2025; 15(1): 93253
Published online Mar 18, 2025. doi: 10.5500/wjt.v15.i1.93253
Lesson learnt from 60 years of liver transplantation: Advancements, challenges, and future directions
Eyad Gadour
Eyad Gadour, Department of Gastroenterology and Hepatology, King Abdulaziz National Guard Hospital, Ahsa 36428, Saudi Arabia
Eyad Gadour, Internal Medicine, Zamzam University College, Khartoum 11113, Sudan
Author contributions: Gadour E contributed to conceptualization, resources, writing, review and editing; and writing the final manuscript; Gadour E read and agreed to the published version of the manuscript.
Conflict-of-interest statement: No conflict of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eyad Gadour, CCST, FACP, FRCP, MRCP, MSc, Adjunct Associate Professor, Department of Gastroenterology and Hepatology, King Abdulaziz National Guard Hospital, National Guard Street, Ahsa 36428, Saudi Arabia. dreyadgadour@gmail.com
Received: February 22, 2024
Revised: September 6, 2024
Accepted: September 14, 2024
Published online: March 18, 2025
Processing time: 278 Days and 14.6 Hours
Core Tip

Core Tip: Over the past 60 years, liver transplantation (LT) has become an effective and well-established curative intervention for patients presenting with acute and chronic liver failure. However, the cost, complexity, and shortage of donor organs for LT has greatly challenged this intervention. Nonetheless, modifications in patient selection criteria resulting in less stringent parameters for LT patient selection, the introduction of neoadjuvant therapies, and the rehabilitation of previously unsalvageable donors have had a significant impact in countering this challenge.