©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Apr 24, 2017; 7(2): 117-128
Published online Apr 24, 2017. doi: 10.5500/wjt.v7.i2.117
Published online Apr 24, 2017. doi: 10.5500/wjt.v7.i2.117
Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation
Siddharth Narayanan, Gopalakrishnan Loganathan, Maheswaran Dhanasekaran, William Tucker, Ankit Patel, SriPrakash Mokshagundam, Michael G Hughes, Stuart K Williams, Appakalai N Balamurugan, Clinical Islet Cell Laboratory, Center for Cellular Transplantation, Cardiovascular Innovation Institute, Department of Surgery, University of Louisville, Louisville, KY 40202, United States
Venugopal Subhashree, School of Biosciences and Technology, VIT University, Vellore 632014, India
Author contributions: All authors contributed to this paper.
Conflict-of-interest statement: None declared.
Correspondence to: Appakalai N Balamurugan, PhD, Clinical Islet Cell Laboratory, Center for Cellular Transplantation, Cardiovascular Innovation Institute, Department of Surgery, University of Louisville, 302 E Muhammad Ali Blvd., Louisville, KY 40202, United States. bala.appakalai@louisville.edu
Telephone: +1-502-7947070 Fax: +1-502-8540558
Received: January 4, 2017
Peer-review started: January 7, 2017
First decision: February 17, 2017
Revised: February 28, 2017
Accepted: March 23, 2017
Article in press: March 24, 2017
Published online: April 24, 2017
Processing time: 106 Days and 3.5 Hours
Peer-review started: January 7, 2017
First decision: February 17, 2017
Revised: February 28, 2017
Accepted: March 23, 2017
Article in press: March 24, 2017
Published online: April 24, 2017
Processing time: 106 Days and 3.5 Hours
Core Tip
Core tip: This review article summarizes recent developments in the cross-talk relationship between intra-islet endothelial cells and beta cells. The molecules involved in the signalling pathways can be potential targets for therapeutic strategies and islet transplantation.