Dursun I, Yel S, Unsur E. Dynamics of circulating microparticles in chronic kidney disease and transplantation: Is it really reliable marker? World J Transplant 2015; 5(4): 267-275 [PMID: 26722654 DOI: 10.5500/wjt.v5.i4.267]
Corresponding Author of This Article
Ismail Dursun, MD, Division of Pediatric Nephrology, Erciyes University, Faculty of Medicine, Melikgazi, 38200 Kayseri, Turkey. drdursun@hotmail.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Dec 24, 2015; 5(4): 267-275 Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.267
Dynamics of circulating microparticles in chronic kidney disease and transplantation: Is it really reliable marker?
Ismail Dursun, Sibel Yel, Emel Unsur
Ismail Dursun, Emel Unsur, Division of Pediatric Nephrology, Erciyes University, Faculty of Medicine, 38200 Kayseri, Turkey
Sibel Yel, Division of Pediatric Nephrology, Emel Mehmet Tarman Children Hospital, Kayseri Teaching and Training Hospital, 38100 Kayseri, Turkey
Author contributions: Dursun I and Yel S equally contributed to coordinate the study and reviewed the literature; Unsur E edited the manuscript; all authors wrote and approved the final graft.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ismail Dursun, MD, Division of Pediatric Nephrology, Erciyes University, Faculty of Medicine, Melikgazi, 38200 Kayseri, Turkey. drdursun@hotmail.com
Telephone: +90-505-9067145 Fax: +90-352-4375825
Received: July 26, 2015 Peer-review started: July 27, 2015 First decision: August 25, 2015 Revised: October 9, 2015 Accepted: November 3, 2015 Article in press: November 4, 2015 Published online: December 24, 2015 Processing time: 150 Days and 6.1 Hours
Core Tip
Core tip: In chronic kidney disease (CKD), cardiovascular disease is a leading cause of mortality and morbidity even after renal transplantation. Classical cardiovascular risk factors are insufficient to explain the entire story in the development of atherosclerosis. The existence of endothelial dysfunction may serve as a marker of a poor cardiovascular outcome. The need for a reliable and clinically significant marker of early vascular disease and endothelial dysfunction in atherosclerosis and early detection of graft rejection in renal transplant recipients is emerging. Although the precise molecular mechanism of microparticle formation is not clear, it has recently emerged as a marker of vascular disease. The dynamics of circulating endothelial microparticles in CKD and transplantation will be reviewed in this manuscript.
