Increase in failed swallows from pre- to post-lung transplant esophageal function testing is associated with acute rejection
Wai-Kit Lo, Pranay Nadella, Natan Feldman, Nirmal Sharma, Hilary J Goldberg, Walter W Chan
Wai-Kit Lo, Natan Feldman, Walter W Chan, Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, Boston, MA 02115, United States
Pranay Nadella, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, United States
Nirmal Sharma, Hilary J Goldberg, Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, MA 02115, United States
Author contributions: Chan WW and Lo WK initiated study concepts and design; Chan WW, Lo WK, Feldman N, Sharma N, and Goldberg HJ contributed to acquisition of data; Chan WW, Lo WK, Sharma N, and Goldberg HJ performed analysis and interpretation of data; Chan WW, Lo WK, and Nadella P drafted the manuscript; Chan WW, Lo WK, Nadella P, Feldman N, Sharma N, and Goldberg HJ contributed to critical revision of manuscript for important intellectual content; Chan WW and Lo WK performed statistical analyses; Chan WW provided administrative support and overall study supervision.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Mass General Brigham Institutional Review Board, approval No. 2011P001563.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items
Data sharing statement: Technical appendix, statistical code, and dataset available upon reasonable request and approval by the Institutional Review Board from the corresponding author at
wwchan@bwh.harvard.edu.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Walter W Chan, MD, AGAF, FACG, Associate Professor, Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, United States.
wwchan@bwh.harvard.edu
Received: March 17, 2025
Revised: April 14, 2025
Accepted: May 21, 2025
Published online: December 18, 2025
Processing time: 247 Days and 21.8 Hours
