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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2025; 15(4): 106938
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.106938
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.106938
Risk factors for autoimmune liver disease recurrence after liver transplantation
Moisés Salgado-de la Mora, Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14080, Mexico
Osvely Mendez-Guerrero, Graciela E Castro Narro, Nalu Navarro-Alvarez, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14080, Mexico
Aldo Torre, Department of Gastroenterology, Centro Médico ABC, Mexico City, 01120, Mexico
Mario Vilatoba, Department of Transplant, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14080, Mexico
Mario Isaac Lumbreras Márquez, Division of Epidemiology and Public Health, Universidad Panamericana School of Medicine, Mexico City, 03920, Mexico
Nalu Navarro-Alvarez, Department of Surgery, University of Colorado Anschutz Medical Campus, Denver, CO 80045, United States
Author contributions: Salgado-de la Mora M was responsible for study concept and design, acquisition of data, analysis and interpretation of data, writing of the original manuscript; Mendez-Guerrero O was responsible for statistical analysis, review and editing; Torre A was responsible for review and editing; Vilatoba M was responsible for review and editing; Castro Narro GE was responsible for review and editing; Lumbreras Márquez MI was responsible for analysis and interpretation of data, statistical analysis, writing of the original manuscript, review and editing; Navarro-Alvarez N was responsible for critical revision of the manuscript for important intellectual content, study supervision, writing of the original manuscript, review and editing; all of the authors read and approved the final version of the manuscript to be published.
Institutional review board statement: This study was approved by our institutional review board with the approval GAS 4670-23-24-1.
Informed consent statement: Given the retrospective nature of the study and the use of de-identified data, the requirement for informed consent was waived in accordance with institutional guidelines and ethical regulations.
Conflict-of-interest statement: The authors declare no conflict of interest exist.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: All relevant data are included in the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nalu Navarro-Alvarez, MD, PhD, Assistant Professor, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, 15 Vasco de Quiroga, Mexico City, 14080, Mexico. nalu.navarroa@incmnsz.mx
Received: March 11, 2025
Revised: May 21, 2025
Accepted: July 25, 2025
Published online: December 18, 2025
Processing time: 253 Days and 12.2 Hours
Revised: May 21, 2025
Accepted: July 25, 2025
Published online: December 18, 2025
Processing time: 253 Days and 12.2 Hours
Core Tip
Core Tip: Autoimmune liver disease (AILD) recurrence after liver transplantation remains a significant concern, yet its predictive factors are not well established. This retrospective cohort study identified higher pre-transplant Child-Pugh and model for end-stage liver disease score, along with alanine aminotransferase > 2 times the upper limit of normal, as significant risk factors for recurrence. Using logistic regression models, we demonstrated a moderate predictive ability for recurrence, though no single model outperformed the others. These findings provide insights into risk stratification, potentially aiding in post-transplant management and surveillance strategies for AILD patients.