Beyond futility: The history and potential of liver transplantation in cholangiocarcinoma

doi:10.5500/wjt.v15.i4.105649

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 15, Issue 4

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (482)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series.

Item

Count

PDF

HTML

137

Figures (1-1)

Sum=232

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

166

Sum=225

Dec 18, 2025 (publication date) through Feb 27, 2026

Times Cited of This Article

Times Cited (1)

Journal Information of This Article

Publication Name

World Journal of Transplantation

ISSN

2220-3230

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Transplant. Dec 18, 2025; 15(4): 105649
Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.105649

Beyond futility: The history and potential of liver transplantation in cholangiocarcinoma

Lynn Affarah, Sreelakshmi Kotha, Philip Berry

Lynn Affarah, Sreelakshmi Kotha, Philip Berry, Department of Hepatology, Guy's and St Thomas' Hospital, London SE1 7JD, United Kingdom

Philip Berry, King's College London, King's Health Partners, London SE1 9RT, London, United Kingdom

Author contributions: Affarah L, Berry P and Kotha S wrote this manuscript; Kotha S and Berry P conceptualised the review. All authors have read and approved the final manuscript.

Conflict-of-interest statement: There are no conflicts of interest.

Corresponding author: Sreelakshmi Kotha, Department of Hepatology, Guy's and St Thomas' Hospital, Westminster Bridge road, London SE1 7JD, United Kingdom. sreelakshmi.kotha@gstt.nhs.uk

Received: February 2, 2025
Revised: May 12, 2025
Accepted: August 20, 2025
Published online: December 18, 2025
Processing time: 291 Days and 11.6 Hours

Core Tip

Core Tip: Liver transplantation (LT) had previously been contraindicated in the treatment of cholangiocarcinoma (CCA). However, recent advances in both oncological treatment and patient-selection criteria have led to a paradigm shift, with various studies showing that patients with locally advanced CCA undergoing LT have promising outcomes. Numerous centers in North America and Europe have now adopted this as standard of care. Organ scarcity is a major factor to be considered. These complex patients are best managed by a multi-disciplinary team.