Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Sep 18, 2024; 14(3): 94914
Published online Sep 18, 2024. doi: 10.5500/wjt.v14.i3.94914
Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study
William Chung, Kevin Wong, Noel Ravindranayagam, Lauren Tang, Josephine Grace, Darren Wong, Danny Con, Marie Sinclair, Avik Majumdar, Numan Kutaiba, Samuel Hui, Paul Gow, Vijayaragavan Muralidharan, Alexander Dobrovic, Adam Testro
William Chung, Kevin Wong, Noel Ravindranayagam, Lauren Tang, Josephine Grace, Darren Wong, Danny Con, Marie Sinclair, Avik Majumdar, Samuel Hui, Paul Gow, Adam Testro, Department of Gastroenterology, Austin Health, Heidelberg 3084, Victoria, Australia
William Chung, Lauren Tang, Josephine Grace, Darren Wong, Marie Sinclair, Avik Majumdar, Paul Gow, Adam Testro, Victorian Liver Transplant Unit, Austin Health, Heidelberg 3084, Victoria, Australia
Numan Kutaiba, Department of Radiology, Austin Health, Heidelberg 3084, Victoria, Australia
Samuel Hui, Department of Gastroenterology, Monash Health, Clayton 3168, Victoria, Australia
Vijayaragavan Muralidharan, Department of Surgery, University of Melbourne, Austin Health, Heidelberg 3048, Victoria, Australia
Alexander Dobrovic, Department of Surgery, Beacon Laboratory, Austin Precinct, The University of Melbourne, Austin Hospital, Heidelberg 3048, Victoria, Australia
Author contributions: Chung W contributed to study design, data collection, statistical analysis, manuscript writing and revision; Wong K, Ravindranayagam N and Tang L contributed to data collection; Grace J, Wong D, Sinclair M, Majumdar A, Kutaiba N, Gow P, Muralidharan V, Dobrovic A and Testro A contributed to study design, assisted with statistical analysis, and provided critical appraisal of the manuscript; Con D and Hui S contributed to assisted with statistical analysis of the study and critical appraisal of manuscript.
Institutional review board statement: This study was approved by the Austin Health Human Ethics Research Committee (No. HREC/87459/Austin-2022).
Informed consent statement: As this was a retrospective study by medical records review, informed consent was not obtained from study participants.
Conflict-of-interest statement: Dobrovic A has received honoraria as a speaker from Bio-Rad. Chung W, Wong K, Ravindranayagam N, Tang L, Grace J, Wong D, Con D, Sinclair M, Majumdar A, Kutaiba N, Hui S, Gow P, Muralidharan V and Testro A do not have any conflicts of interests to declare.
Data sharing statement: De-identified patient data may be provided upon request at william.chung2@austin.org.au.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: William Chung, FRACP, MBBS, Attending Doctor, Doctor, Research Fellow, Staff Physician, Department of Gastroenterology, Austin Health, No. 145 Studley Road, Heidelberg 3084, Victoria, Australia. william.chung2@austin.org.au
Received: March 28, 2024
Revised: May 13, 2024
Accepted: May 30, 2024
Published online: September 18, 2024
Processing time: 125 Days and 7.5 Hours
Core Tip

Core Tip: In this single centre, retrospective study of adult patients who received liver transplantation (LT) for Hepatocellular carcinoma in Australia, statin, aspirin or metformin use after LT was not associated with a difference in the composite endpoint of hepatocellular carcinoma (HCC)-recurrence and all-cause mortality, HCC-recurrence or HCC-related mortality.