Randomized Controlled Trial
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jul 18, 2022; 12(7): 184-194
Published online Jul 18, 2022. doi: 10.5500/wjt.v12.i7.184
Metabolic and functional effects of exercise training in diabetic kidney transplant recipients
Vassiliki Michou, Maria Nikodimopoulou, Asterios Deligiannis, Evangelia Kouidi
Vassiliki Michou, Asterios Deligiannis, Evangelia Kouidi, Sports Medicine Laboratory, School of Physical Education & Sport Science, Aristotle University, Thessaloniki 57001, Greece
Maria Nikodimopoulou, Transplant Surgery Clinic of Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki 54642, Greece
Author contributions: Michou V designed this study and collected and analyzed the data; Michou V, Koudi E and Deligiannis A drafted the manuscript and gave final approval of the version to be published; Michou V and Koudi E took part in this study as cardiopulmonary exercise testing operators or assistants; Nikodimopoulou M recruited diabetic kidney transplant recipients to participate to the study.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the Aristotle University of Thessaloniki (Protocol number:117461/2019).
Clinical trial registration statement: This study is registered at Laboratory of Sports Medicine, Aristotle University of Thessaloniki, TEFAA.
Informed consent statement: All study participant received all the necessary study information before the study enrollment and provided written informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Evangelia Kouidi, Doctor, PhD, Professor, Sports Medicine Laboratory, School of Physical Education & Sport Science, Aristotle University, Laboratory Building (3rd Floor), Thessaloniki 57001, Greece. kouidi@phed.auth.gr
Received: January 12, 2022
Peer-review started: January 12, 2022
First decision: March 16, 2022
Revised: April 20, 2022
Accepted: June 16, 2022
Article in press: June 16, 2022
Published online: July 18, 2022
Processing time: 183 Days and 7.1 Hours
Core Tip

Core Tip: Physical activity levels are significantly lower in kidney transplant (KT) recipients compared to the general population. The effects of exercise training in KT recipients with diabetes mellitus remain unclear, and so little is known about the role of increased exercise on cardiovascular risk and metabolic profile of KT patients. This randomized controlled trial aimed to investigate the effects of a 6-mo home-based exercise training program on functional capacity, glucose levels and lipid profile of diabetic KT patients. The results of the present study demonstrated that a long-term exercise training program is feasible and effective in diabetic KT recipients.