Current status of glucocorticoid usage in solid organ transplantation

doi:10.5500/wjt.v11.i11.443

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Nov 18, 2021 (publication date) through Mar 8, 2026

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Nov 18, 2021; 11(11): 443-465
Published online Nov 18, 2021. doi: 10.5500/wjt.v11.i11.443

Current status of glucocorticoid usage in solid organ transplantation

Simin Dashti-Khavidaki, Reza Saidi, Hong Lu

Simin Dashti-Khavidaki, Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14155, Iran

Reza Saidi, Department of Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, United States

Hong Lu, Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY 13210, United States

Author contributions: Dashti-Khavidaki S and Lu H designed the report; Dashti-Khavidaki S wrote the paper; Saidi R and Lu H revised the paper.

Conflict-of-interest statement: Authors declare no conflict of interest for this article.

Corresponding author: Hong Lu, PhD, Assistant Professor, Department of Pharmacology, SUNY Upstate Medical University, Syracuse NY 13210, United States. luh@upstate.edu

Received: May 27, 2021
Peer-review started: May 27, 2021
First decision: July 28, 2021
Revised: September 16, 2021
Accepted: November 3, 2021
Article in press: November 3, 2021
Published online: November 18, 2021
Processing time: 168 Days and 11.5 Hours

Core Tip

Core Tip: Due to their potent immunosuppressive and anti-inflammatory effects, glucocorticoids (GCs) are widely used in solid organ transplantation (SOT). We review the current status of GC usage in SOT, including the different clinical uses in transplant recipients and donors, new strategies for targeted organ delivery of GCs, and enhancement of immune-tolerance vs immunosuppressive effects. Major concerns about GCs, such as their adverse effects on various organs and their potential drug-drug interactions in SOT patients, are also discussed.