Khalil MAM, Rajput AS, Khalil MSU, Ullah SR, Ghani R, Daiwajna RG, Hong LK, Tan J. Multidisciplinary care of kidney donation in Brugada syndrome: A case report. World J Transplant 2025; 15(4): 107839 [DOI: 10.5500/wjt.v15.i4.107839]
Corresponding Author of This Article
Muhammad Abdul Mabood Khalil, FRCP (C), Department of Nephrology, Raja Isteri Pengiran Anak Saleha Hospital, Al Kurnaysh Br Road, Al Andalus, Bander Seri Begawan BA1712, Brunei Darussalam. doctorkhalil1975@hotmail.com
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Transplantation
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Case Report
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 18, 2025 (publication date) through Nov 18, 2025
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Publication Name
World Journal of Transplantation
ISSN
2220-3230
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Khalil MAM, Rajput AS, Khalil MSU, Ullah SR, Ghani R, Daiwajna RG, Hong LK, Tan J. Multidisciplinary care of kidney donation in Brugada syndrome: A case report. World J Transplant 2025; 15(4): 107839 [DOI: 10.5500/wjt.v15.i4.107839]
World J Transplant. Dec 18, 2025; 15(4): 107839 Published online Dec 18, 2025. doi: 10.5500/wjt.v15.i4.107839
Multidisciplinary care of kidney donation in Brugada syndrome: A case report
Muhammad Abdul Mabood Khalil, Ahmed Suleman Rajput, Muhammad Shahab Uddin Khalil, SM Rahmat Ullah, Ruzita Ghani, Rajendra Govindrao Daiwajna, Lim Kim Hong, Jackson Tan
Muhammad Abdul Mabood Khalil, Ahmed Suleman Rajput, SM Rahmat Ullah, Ruzita Ghani, Rajendra Govindrao Daiwajna, Jackson Tan, Department of Nephrology, Raja Isteri Pengiran Anak Saleha Hospital, Bander Seri Begawan BA1712, Brunei Darussalam
Muhammad Shahab Uddin Khalil, Department of Cardiology, Hayatabad Medical Complex, Peshawar 25000, Pakistan
Lim Kim Hong, Department of Anesthesia, Raja Isteri Pengiran Anak Saleha Hospital, Bander Seri Begawan BA1712, Brunei Darussalam
Author contributions: Khalil MAM wrote the case report; Rajput AS, Khalil MSU, Ullah SMR, Ghani R, Daiwajna RG, Hong LK, and Tan J helped in literature search and supported in writing. All authors read and agreed to the final manuscript.
Informed consent statement: The patient gave his informed consent for the publication of this paper and its corresponding images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammad Abdul Mabood Khalil, FRCP (C), Department of Nephrology, Raja Isteri Pengiran Anak Saleha Hospital, Al Kurnaysh Br Road, Al Andalus, Bander Seri Begawan BA1712, Brunei Darussalam. doctorkhalil1975@hotmail.com
Received: March 31, 2025 Revised: April 22, 2025 Accepted: June 7, 2025 Published online: December 18, 2025 Processing time: 234 Days and 12.3 Hours
Abstract
BACKGROUND
Brugada syndrome (BS) is a rare disorder affecting approximately 5 in every 10000 people. Reports of kidney donation in individuals with BS are exceptionally uncommon.
CASE SUMMARY
The decision to permit live kidney donation places significant responsibility on clinicians. Donors must adapt to life with a single kidney. While the risk of developing chronic kidney disease post-donation is minimal, it remains higher than in matched healthy individuals. Additionally, the theoretical risk of electrolyte imbalances in kidney donors with BS may have important clinical implications. We present a case of successful kidney donation by a donor with an incidental diagnosis of a sporadic case of BS type 1. An extensive electrophysiological evaluation was conducted to assess the risk of arrhythmia to approval for donation. Anesthetic management was meticulously planned, and the donor was monitored postoperatively in a coronary care unit for 48 hours. This case underscores the ethical considerations and the multidisciplinary approach necessary to ensure donor safety.
CONCLUSION
Kidney donation in individuals with BS requires careful evaluation to mitigate the risk of fatal arrhythmias during surgical and anesthetic stress. With comprehensive preoperative assessment and vigilant perioperative management, kidney donation can be performed safely.
Core Tip: This case describes a successful kidney donation in a patient with newly diagnosed Brugada syndrome (BS). This case report describes the ethical dilemma and ensuring donor safety in the long run and shares our experience while managing a kidney donor with BS. To our knowledge, this is the first report describing kidney donation in patients with BS.
