Published online Jun 18, 2024. doi: 10.5500/wjt.v14.i2.90825
Revised: January 23, 2024
Accepted: April 1, 2024
Published online: June 18, 2024
Processing time: 182 Days and 14.5 Hours
Kidney transplantation leads to continuous improvement in the survival rates of kidney transplant recipients (KTRs) and has been established as the treatment of choice for patients with end-stage kidney disease. Health-related quality of life (HRQoL) has become an important outcome measure. It is highly important to develop reliable methods to evaluate HRQoL with disease-specific questionnaires.
To translate the disease-specific instrument Kidney Transplant Questionnaire 25 (KTQ-25) to the Greek language and perform a cross-cultural adaptation.
The translation and adaptation of the original English version of the KTQ-25 to the Greek language were performed based on the International Quality of Life Assessment.
Eighty-four KTRs (59 males; mean age 53.5 ± 10.7 years; mean estimated glomerular filtration rate 47.7 ± 15.1 mL/min/1.73 m2; mean transplant vintage 100.5 ± 83.2 months) completed the Greek version of the KTQ-25 and the 36-item Short-Form Health Survey, and the results were used to evaluate the reliability of the Greek KTQ-25. The Cronbach alpha coefficients for all the KTQ-25 dimensions were satisfactory (physical symptoms = 0.639, fatigue = 0.856, uncertainty/fear = 0.661, appearance = 0.593, emotions = 0.718, total score = 0.708). The statistically significant correlation coefficients among the KTQ-25 dimensions ranged from 0.226 to 0.644. The correlation coefficients of the KTQ-25 dimensions with the SF-36 physical component summary (PCS) ranged from 0.196 to 0.550; the correlation coefficients of the KTQ-25 with the SF-36 mental component summary (MCS) ranged from 0.260 to 0.655; and the correlation coefficients of the KTQ-25 with the total scores with the SF-36 PCS and MCS were 0.455 and 0.613, respectively.
According to the findings, the Greek version of the KTQ-25 is valid and reliable for administration among kidney transplant patients in Greece.
Core Tip: The Kidney Transplant Questionnaire 25 (KTQ-25) is a disease-specific instrument that is used to evaluate the health-related quality of life of patients who suffer from end-stage kidney disease and who have undergone kidney transplantation. Prior to this study, there was no disease-specific instrument for these patients in our country. We translated the KTQ-25 into Greek according to the International Quality of Life Assessment. The translated version of the KTQ-25 was administered to a Greek cohort of kidney transplant recipients. Scores of the five dimensions of the KTQ-25 were calculated, and statistical tests were performed to estimate the reliability and validity of the translated scale.