Clinical efficacy of Sihai Shuyu Pill-Euthyrox for thyroid nodules and real-world research on patients’ anxiety/depression

Table 1 Comparison of clinical efficacy between two groups of patients, n (%)

Grouping	Healing	Take effect	Effective	Ineffective	Overall efficacy
Control group (n = 60)	4 (6.67)	23 (38.33)	28 (46.67)	5 (8.33)	55 (91.67)
Experimental group (n = 60)	8 (13.33)	36 (60.00)	15 (25.00)	1 (1.67)	59 (98.33)
χ2 value					10.793
P value					0.013

Table 2 Comparison of thyroid nodules before and after treatment in two groups of patients, mean ± SD

Grouping	Volume of thyroid nodules (mL)		Number of thyroid nodules (units)		Maximum nodule diameter (mm)
	Before intervention	After the intervention	Before the intervention	After the intervention	Before the intervention	After the intervention
Control group (n = 60)	14.84 ± 2.51	12.35 ± 2.23a	2.29 ± 1.02	1.87 ± 0.85a	16.98 ± 1.95	15.26 ± 1.87a
Experimental group (n = 60)	14.67 ± 2.17	9.88 ± 1.98a	2.35 ± 0.94	1.52 ± 0.76a	16.37 ± 2.15	13.55 ± 1.68a
t value	0.837	4.521	0.395	2.135	0.748	2.376
P value	0.185	0.008	0.674	0.035	0.214	0.020

^aP < 0.05 vs before the intervention.

Table 3 Comparison of thyroid function indicators before and after treatment between the two groups of patients, mean ± SD

Grouping	TSH (μIU/mL)		FT3 (pg/mL)		FT4 (pg/mL)
	Before intervention	After the intervention	Before the intervention	After the intervention	Before the intervention	After the intervention
Control group (n = 60)	1.95 ± 0.86	1.43 ± 0.67a	3.24 ± 1.05	2.12 ± 0.83a	0.95 ± 0.14	0.86 ± 0.14a
Experimental group (n = 60)	1.92 ± 0.95	1.07 ± 0.53a	3.18 ± 1.14	2.06 ± 0.77a	0.97 ± 0.20	0.83 ± 0.17a
t value	0.584	2.958	0.854	1.047	0.674	1.121
P value	0.445	0.034	0.181	0.076	0.411	0.069

^aP < 0.05 vs before the intervention.

TSH: Thyroid stimulating hormone; FT3: Free triiodothyronine; FT4: Free thyroxine.

Table 4 Comparison of anxiety and depression before and after treatment between the two groups, mean ± SD

Grouping	SDS		SAS
	Before intervention	After the intervention	Before the intervention	After the intervention
Control group (n = 60)	53.84 ± 5.92	49.01 ± 3.04a	53.24 ± 5.42	50.31 ± 6.77a
Experimental group (n = 60)	53.04 ± 5.94	43.93 ± 6.4a	53.98 ± 5.83	44.34 ± 4.88a
t value	0.527	3.251	0.842	3.395
P value	0.486	0.028	0.184	0.024

^aP < 0.05 vs before the intervention.

SDS: Self-Rating Depression Scale; SAS: Self-Rating Anxiety Scale.

Table 5 Comparison of incidence of adverse reactions between the two groups, n (%)

Grouping	Gastrointestinal discomfort	Allergy	Headache	Palpitations	Others	Total incidence rate
Control group (n = 60)	5 (8.33)	2 (3.33)	2 (3.33)	1 (1.67)	1 (1.67)	11 (18.33)
Experimental group (n = 60)	3 (5.00)	1 (1.67)	1 (1.67)	0	1 (1.67)	6 (10.00)
χ2 value						0.958
P value						0.215