Clinical efficacy of Sihai Shuyu Pill-Euthyrox for thyroid nodules and real-world research on patients’ anxiety/depression
Jing Deng, Ling Wang, Medical College, Macau University of Science and Technology, Macau Special Administrative Region 999078, China
Jing Deng, Department of Medical, Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Yu-Xing Xiao, Medical College, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China
Chong Zhang, Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan Province, China
Co-corresponding authors: Ling Wang and Chong Zhang.
Author contributions: Deng J, Wang L, and Zhang C contributed to conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology; Deng J, Xiao YX, Wang L, and Zhang C contributed to project administration, resources, software, supervision, validation, visualization, writing the original draft, and review and editing; Wang L and Zhang C contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors have read and approved the final manuscript.
Supported by the Key Project of Sichuan Medical Association, No. WT2025RXSN01; Open Project of Key Laboratory of Sichuan University, No. 30320220035; and Scientific Research Project of Sichuan Provincial People’s Hospital, No. 2021Zx09.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Sichuan Provincial People’s Hospital, approval No. 2024-651-1.
Clinical trial registration statement: This study has been registered on the International Traditional Medicine Clinical Trials Registry platform. Registration No. ITMCTR2025000751.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Corresponding author: Chong Zhang, PhD, Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, No. 32 Section 1, West Street, Qingyang District, Chengdu 610072, Sichuan Province, China.
zhangchong77@yeah.net
Received: December 26, 2025
Revised: February 12, 2026
Accepted: April 3, 2026
Published online: July 19, 2026
Processing time: 184 Days and 14.8 Hours
