Significance of arterial spin labeling in relation to sertraline treatment response in adolescents with major depressive disorder

Table 1 Demographic and clinical characteristics of adolescents with major depressive disorder, mean ± SD

Item	Pre-treatment (n = 33)	Post-treatment (n = 33)	t	P value
Gender (female/male)	24/9	24/9	-	-
Age (years)	15.18 ± 1.93	15.18 ± 1.93	-	-
Education (years)	9.15 ± 1.50	9.15 ± 1.50	-	-
HAMD-17	23.48 ± 3.83	12.79 ± 6.36	11.467	< 0.001

HAMD-17: 17-item Hamilton Depression Rating Scale.

Table 2 Regional cerebral blood flow in the right insular cortex before and after sertraline treatment, mean ± SD

CBF value (mL/100 g/minute)	Pre-treatment (n = 33)	Post-treatment (n = 33)	t	P value
Insula_R	66.71 ± 7.91	62.72 ± 6.39	4.751	< 0.001

CBF: Cerebral blood flow.

Table 3 Responders vs non-responders (17-item Hamilton Depression Rating Scale and right insular cerebral blood flow), mean ± SD

Group	HAMD-17 baseline	HAMD-17 post treatment	P value	Insula_R CBF baseline	Insula_R CBF post-treatment	P value
Responders (n = 17)	22.59 ± 3.32	8.06 ± 3.60	< 0.001	67.35 ± 8.03	61.42 ± 5.89	< 0.001
Non-responders (n = 16)	24.44 ± 4.21	17.81 ± 4.51	0.077	66.02 ± 7.81	64.12 ± 6.62	0.053

HAMD-17: 17-item Hamilton Depression Rating Scale; Insula_R: Right insular; CBF: Cerebral blood flow.