Correlation of anxiety/depression status with stress-related markers and cancer-related fatigue in patients with colon cancer

Table 1 Prevalence of anxiety and depression among 120 colon cancer patients

Category	n = 120
SAS (points)	45.58 ± 8.72
Normal (< 50)	84 (70.00)
Mild (50-59)	31 (25.83)
Moderate (60-69)	5 (4.17)
Severe (≥ 70)	0 (0.00)
SDS (points)	51.02 ± 7.64
Normal (< 53)	74 (61.67)
Mild (53-62)	37 (30.83)
Moderate (63-72)	9 (7.50)
Severe (≥ 73)	0 (0.00)
Anxiety or depression	62 (51.67)
Anxiety and depression	20 (16.67)

Data were showed as n (%) or mean ± SD. SAS: Self-Rating Anxiety Scale; SDS: Self-Rating Depression Scale.

Table 2 Association of anxiety and depression with stress-related markers and cancer-related fatigue

Category	SAS (points)		SDS (points)
	r value	P value	r value	P value
HSP70 (ng/mL)	0.379	< 0.001	0.287	0.002
CRP (mg/L)	0.299	< 0.001	0.331	< 0.001
BFI-C (points)	0.398	< 0.001	0.283	0.002

SAS: Self-Rating Anxiety Scale; SDS: Self-Rating Depression Scale; HSP70: Heat shock protein 70; CRP: C-reactive protein; BFI-C: Brief Fatigue Inventory-Chinese version.

Table 3 Univariate analysis of potential predictors for anxiety/depression

Factors	n	Anxiety/depression group (n = 62)	Control group (n = 58)	χ2	P value
Gender				6.318	0.012
Male	73	31 (50.00)	42 (72.41)
Female	47	31 (50.00)	16 (27.59)
Age (years)				9.522	0.002
< 60	55	20 (32.26)	35 (60.34)
≥ 60	65	42 (67.74)	23 (39.66)
Marital status				6.541	0.011
Married	96	48 (77.42)	48 (82.76)
Unmarried/widowed/divorced	24	14 (22.58)	10 (17.24)
Educational level				0.534	0.465
< High school	85	44 (70.97)	41 (70.69)
≥ High school	35	18 (29.03)	17 (29.31)
Employment status				0.769	0.381
Employed	53	25 (40.32)	28 (48.28)
Retired	67	37 (59.68)	30 (51.72)
Monthly household income (RMB)				4.097	0.043
< 4000	83	48 (77.42)	35 (60.34)
≥ 4000	37	14 (22.58)	23 (39.66)
Surgical approach				2.157	0.340
Dixon operation	36	20 (32.26)	16 (27.59)
Miles operation	67	31 (50.00)	36 (62.07)
Sphincter-preserving surgery	17	11 (17.74)	6 (10.34)
Tumor stage				6.486	0.011
II	58	23 (37.10)	35 (60.34)
III-IV	62	39 (62.90)	23 (39.66)
Comorbidities				3.922	0.048
No	53	22 (35.48)	31 (53.45)
Yes	67	40 (64.52)	27 (46.55)

Data were showed as n (%).

Table 4 Multivariate analysis of independent predictors for anxiety/depression

Category	B	SE	Wald	P value	Exp(B)	95%CI
Gender	1.014	0.424	5.725	0.017	2.755	1.201-6.320
Age (years)	0.974	0.417	5.455	0.020	2.649	1.170-6.001
Marital status	0.227	0.513	0.196	0.658	1.255	0.459-3.433
Monthly household income (RMB)	-0.805	0.455	3.134	0.077	0.447	0.183-1.090
Tumor stage	0.854	0.411	4.320	0.038	2.349	1.050-5.254
Comorbidities	0.418	0.420	0.991	0.319	1.520	0.667-3.463