Influencing factors and construction of a nomogram for post-stroke depression in patients with chronic stroke

Table 1 Demographic characteristics of the two patient groups, n (%)

Factors	n	PSD group (n = 96)	NPSD group (n = 104)	χ2	P value
Gender				0.329	0.566
Male	142	70 (72.92)	72 (69.23)
Female	58	26 (27.08)	32 (30.77)
Age (years)				5.592	0.018
< 60	109	44 (45.83)	65 (62.50)
≥ 60	91	52 (54.17)	39 (37.50)
Marital status				6.586	0.010
Married	159	69 (71.88)	90 (86.54)
Divorced/widowed	41	27 (28.13)	14 (13.46)
Education level				9.944	0.002
Below senior high school	106	62 (64.58)	44 (42.31)
Senior high school or above	94	34 (35.42)	60 (57.69)

PSD: Post-stroke depression; NPSD: Non-post-stroke depression.

Table 2 Clinicopathological data of the two patient groups, n (%)

Factors	n	PSD group (n = 96)	NPSD group (n = 104)	χ2	P value
Number of comorbid conditions				11.836	0.003
0	35	23 (23.96)	12 (11.54)
1	108	40 (41.67)	68 (65.38)
≥ 2	57	33 (34.38)	24 (23.08)
Severity of neurological impairment				8.144	0.017
Mild	40	12 (12.50)	28 (26.92)
Moderate	123	61 (66.67)	62 (59.62)
Severe	37	23 (23.96)	14 (13.46)
Lesion location				0.131	0.936
Frontal lobe	90	44 (45.83)	46 (44.23)
Temporal lobe	65	30 (31.25)	35 (33.65)
Basal ganglia	45	22 (22.92)	23 (22.12)
Number of lesions				5.998	0.014
Single	78	29 (30.21)	49 (47.12)
Multiple	122	67 (69.79)	55 (52.88)

PSD: Post-stroke depression; NPSD: Non-post-stroke depression.

Table 3 Blood biochemical indicators of the two patient groups

Factors	n	PSD group (n = 96)	NPSD group (n = 104)	t value	P value
MPV (fL)	200	9.86 ± 1.27	9.58 ± 1.49	1.424	0.156
Lymphocyte count (109/L)	200	1.58 ± 0.50	1.62 ± 0.53	0.548	0.584
Monocyte count (109/L)	200	0.40 ± 0.13	0.42 ± 0.14	1.044	0.298
Neutrophil count (109/L)	200	4.31 ± 0.54	4.06 ± 1.20	1.873	0.063
NLR	200	2.62 ± 0.83	2.03 ± 0.88	4.868	< 0.001
PLR	200	152.77 ± 31.30	130.68 ± 29.22	5.162	< 0.001
LMR	200	4.14 ± 1.08	4.16 ± 1.18	0.125	0.901

PSD: Post-stroke depression; NPSD: Non-post-stroke depression; MPV: Mean platelet volume; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio.

Table 4 Assignment of variables

Factors	Variable	Assignment
Age (years)	X1	< 60 = 0, ≥ 60 = 1
Marital status	X2	Married = 0, divorced/widowed = 1
Education level	X3	Senior high school or above = 0, below senior high school = 1
Number of comorbid conditions	X4	0 = 0, 1 = 1, ≥ 2 = 2
Severity of neurological impairment	X5	Mild = 0, moderate = 1, severe = 2
Number of lesions	X6	Single = 0, multiple = 1
NLR	X7	Continuous variable
PLR	X8	Continuous variable
Post-stroke depression	Y	No = 0, yes = 1

NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio.

Table 5 Binary logistic regression analysis of risk factors for post-stroke depression

Factors	β	SE	Wald	P value	Exp (β)	95%CI
Age (years)	-1.023	0.686	2.223	0.136	0.359	0.094-1.380
Marital status	0.796	0.500	2.531	0.112	2.216	0.831-5.906
Education level	1.718	0.862	3.969	0.046	5.574	1.028-30.214
Number of comorbid conditions	0.105	0.276	0.145	0.703	1.111	0.647-1.907
Severity of neurological impairment	0.460	0.284	2.617	0.106	1.584	0.907-2.766
Number of lesions	0.169	0.694	0.059	0.808	1.184	0.304-4.615
NLR	0.780	0.207	14.175	< 0.001	2.181	1.453-3.274
PLR	0.027	0.006	19.528	< 0.001	1.028	1.015-1.040

NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio.