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Retrospective Cohort Study
Copyright ©The Author(s) 2025.
World J Psychiatry. Nov 19, 2025; 15(11): 106956
Published online Nov 19, 2025. doi: 10.5498/wjp.v15.i11.106956
Table 1 Comparison of general data between the two groups, n (%)
Index
Intervention group (n = 60)
Control group (n = 55)
P value
Age (years), mean ± SD68.5 ± 8.267.8 ± 7.50.712
Gender
Male35 (58.3)34 (61.8)0.621
Female25 (41.7)21 (38.2)0.621
Age of diagnosis (years), mean ± SD62.0 ± 10.561.5 ± 9.80.812
Duration of diabetes (years), mean ± SD8.6 ± 5.28.3 ± 4.90.725
Duration of DFU (months), mean ± SD6.0 ± 3.15.8 ± 2.90.668
Smoking history-0.762-
Active smoking15 (25.0)12 (21.8)-
Previous/never smoker45 (75.0)43 (78.2)-
Hypertension32 (53.3)30 (54.5)0.882
Dyslipidemia28 (46.7)27 (49.1)0.826
Overweight/obesity30 (50.0)29 (52.7)0.842
BMI (kg/m2), mean ± SD28.1 ± 4.727.9 ± 4.60.579
Systolic blood pressure (mmHg), mean ± SD135.6 ± 15.3133.2 ± 14.70.347
Diastolic blood pressure (mmHg), mean ± SD85.4 ± 10.284.5 ± 9.80.422
Hemoglobin (g/dL), mean ± SD13.5 ± 1.213.3 ± 1.10.384
WBC (× 109/L), mean ± SD9.2 ± 2.19.5 ± 2.40.532
Platelet (× 109/L), mean ± SD250 ± 50245 ± 480.717
Albumin (g/dL), mean ± SD3.8 ± 0.53.7 ± 0.40.597
ALT (mmol/L), mean ± SD24.1 ± 6.523.8 ± 6.00.683
eGFR (mL/minute/1.73 m2), mean ± SD85.6 ± 10.384.5 ± 9.70.606
Table 2 Comparison of ulcer location distribution between the two groups, n (%)
Place of the ulcer
Intervention group (n = 60)
Control group (n = 55)
P value
Calcaneus12 (20.0)10 (18.2)0.873
Dorsum10 (16.7)12 (21.8)0.541
Metatarsus14 (23.3)13 (23.6)0.98
Toes9 (15.0)8 (14.5)0.951
Midfoot15 (25.0)12 (21.8)0.643
Table 3 Comparison of wound healing rates between the two groups
Group
Wound healing rate (%)
Number of participants (n)
Number of healed wounds
Intervention group91.76055
Control group76.45542
Table 4 Comparison of Hamilton Anxiety and Hamilton Depression scores between the two groups
Index
Control group (n = 55)
Intervention group (n = 60)
P value
HAMA18.37 ± 3.0213.01 ± 2.13< 0.001
HAMD17.35 ± 2.9512.93 ± 2.040.002