Investigation of the quality of life, mental status in patients with gynecological cancer and its influencing factors

Table 1 European Organization for Research and Treatment on Cancer Quality of Life Questionnaire Core 30 scores of patients

n = 160	1 week after surgery	1 month after surgery	3 months after surgery	6 months after surgery	F	P value
Physical functioning	80.31 ± 4.28	84.14 ± 4.52	87.04 ± 4.05	89.96 ± 5.16	133.0	< 0.0001
Role functioning	81.77 ± 5.20	83.73 ± 4.61	86.72 ± 6.34	89.84 ± 4.50	73.25	< 0.0001
Emotional functioning	65.59 ± 4.01	68.17 ± 4.27	70.61 ± 7.34	73.99 ± 7.14	58.90	< 0.0001
Cognitive functioning	83.87 ± 6.09	86.53 ± 5.06	87.91 ± 4.68	88.74 ± 5.09	26.39	< 0.0001
Social functioning	64.09 ± 3.77	66.20 ± 5.74	69.39 ± 2.16	70.38 ± 3.60	82.90	< 0.0001
Global health status	65.49 ± 5.75	69.01 ± 4.70	72.33 ± 3.37	76.39 ± 3.63	174.0	< 0.0001
Fatigue	18.71 ± 1.17	19.58 ± 1.46	20.61 ± 2.33	21.44 ± 2.73	55.82	< 0.0001
Nausea and vomiting	10.17 ± 1.94	10.13 ± 1.83	8.94 ± 1.68	7.44 ± 1.27	91.87	< 0.0001
Pain	23.36 ± 3.55	24.38 ± 5.01	25.30 ± 3.05	26.25 ± 6.46	11.02	< 0.0001
Dyspnea	8.28 ± 1.03	7.97 ± 1.14	7.46 ± 0.93	6.82 ± 1.09	59.47	< 0.0001
Insomnia	19.89 ± 3.82	21.40 ± 4.43	21.81 ± 4.17	21.83 ± 4.95	7.033	0.0001
Appetite loss	6.33 ± 1.17	6.18 ± 1.12	5.44 ± 0.81	5.64 ± 1.04	26.43	< 0.0001
Constipation	4.50 ± 0.56	4.78 ± 0.47	4.25 ± 0.58	4.16 ± 0.84	31.88	< 0.0001
Diarrhea	3.76 ± 0.62	3.71 ± 0.77	3.54 ± 0.73	3.47 ± 0.58	6.585	0.0002
Financial problems	50.65 ± 5.60	52.54 ± 4.52	54.63 ± 5.47	54.98 ± 5.01	24.26	< 0.0001

Table 2 Functional Assessment of Cancer Therapy-General Questionnaire scores of patients

	1 week after surgery	1 month after surgery	3 months after surgery	6 months after surgery	F	P value
Physical well-being	20.19 ± 1.30	21.61 ± 1.47	23.69 ± 1.57	24.84 ± 1.26	351.0	< 0.0001
Social and family well-being	13.73 ± 1.40	18.17 ± 1.19	19.46 ± 1.23	20.17 ± 1.29	124.3	< 0.0001
Emotional well-being	18.24 ± 1.36	19.34 ± 1.11	20.24 ± 1.31	21.28 ± 1.38	159.1	< 0.0001
Functional well-being	14.58 ± 1.08	14.81 ± 1.07	16.13 ± 1.25	18.66 ± 1.38	387.7	< 0.0001
FACT-G total score	70.74 ± 2.43	73.93 ± 2.24	79.52 ± 2.86	84.94 ± 2.78	934.5	< 0.0001

FACT-G: Functional Assessment of Cancer Therapy-General Questionnaire.

Table 3 Univariate analysis of influencing factors of anxiety

	Anxiety (n = 30)	Non-anxiety (n = 130)	χ2	P value
Age (years)			0.401	0.527
< 45	14	69
≥ 45	16	61
Tumor type			0.489	0.783
Carcinoma of the cervix	10	48
Carcinoma of the vulva	5	26
Endometrial carcinoma	15	56
Ethnicity			0.036	0.849
Han	20	89
Ethnic minorities	10	41
Education level			0.312	0.577
High school and below	17	87
Bachelor’s degree or above	13	43
Residence			0.041	0.839
Rural	16	72
Urban	14	58
Payment mode for medical expenses			0.173	0.677
Medical insurance payouts	22	100
Out-of-pocket payment	8	30
Annual household income (ten thousand CNY)			9.842	0.002
< 5	20	46
≥ 5	10	84
Marital status			0.390	0.532
Married	19	90
Unmarried, divorced, or widowed	11	40
Number of children born			2.342	0.310
None	5	39
1	16	62
≥ 2	9	29
Working status			6.333	0.012
Employed	14	92
Unemployed or resigned	16	38
Body pain			16.381	< 0.0001
With	22	43
Without	8	87
Daily sleep duration (hour)			15.511	< 0.0001
< 6	20	37
≥ 6	10	93

Table 4 Univariate analysis of influencing factors of depression

	Depression (n = 29)	Non-depressive (n = 131)	χ2	P value
Age (years)			1.563	0.211
< 45	12	71
≥ 45	17	60
Tumor type			0.064	0.969
Carcinoma of the cervix	10	48
Carcinoma of the vulva	6	25
Endometrial carcinoma	13	58
Ethnicity			0.111	0.739
Han	19	90
Ethnic minorities	10	41
Education level			5.985	0.014
High school and below	8	69
Bachelor’s degree or above	21	62
Residence			0.188	0.665
Rural	17	71
Urban	12	60
Payment mode for medical expenses			0.183	0.669
Medical insurance payouts	23	99
Out-of-pocket payment	6	32
Annual household income (ten thousand CNY)			4.410	0.036
< 5	17	49
≥ 5	12	82
Marital status			0.300	0.584
Married	21	88
Single, divorced, or widowed	8	43
Number of children born			0.204	0.903
None	8	36
1	15	63
≥ 2	6	32
Working status			0.063	0.801
Employed	19	89
Unemployed or resigned	10	42
Body pain			30.511	< 0.0001
Yes	25	40
No	4	91
Daily sleep duration (hour)			25.011	< 0.0001
< 6	22	35
≥ 6	7	96

Table 5 Logistic regression analysis of influencing factors of anxiety and depression

Variables	β	SE	Wald	P value	HR	95%CI
Anxiety
Annual household income ≥ 50000 CNY	-0.792	0.481	2.710	0.100	0.453	0.176-1.163
Employed	-0.853	0.500	2.915	0.088	0.426	0.160-1.134
Presence of body pain	1.551	0.486	10.172	0.001	4.716	1.818-12.232
Sleep duration ≥ 6 hours	-1.581	0.496	10.147	0.001	0.206	0.078-0.544
Depression
Educational level: Bachelor’s degree or above	0.461	0.563	0.671	0.413	1.586	0.526-4.784
Presence of body pain	2.861	0.626	20.455	0.000	16.964	4.974-57.857
Sleep duration ≥ 6 hours	-2.278	0.572	15.861	0.000	0.103	0.033-0.315

β: Intercept; SE: Standard error; Wald: Chi-square value; HR: Hazard ratio; 95%CI: 95% confidence interval.