Clinical efficacy of Baijin pills in the treatment of generalized tonic-clonic seizure epilepsy with cognitive impairment

Table 1 Characteristics of patients

	Experimental group	Control group
Sample size	40	40
Female	20	18
Age (yr)	40.92 ± 13.51	42.37 ± 12.3
Clinical course	5.65 ± 2.34	5.91 ± 1.62
Education background
Bachelor's degree or above	8	10

Table 2 The frequency, duration, and difference of seizures before and after treatment were compared between the two groups

Group	Sample size	Period	Attack frequency/6 months	Seizure duration (min/time)
Experiment group	40	Before treatment	12.60 ± 6.00	3.55 ± 1.75
		After treatment	8.77 ± 5.75	1.62 ± 1.55
		The difference before and after treatment	3.82 ± 1.53	2.49 ± 0.83
Control group	40	Before treatment	12.98 ± 6.26	3.75 ± 1.69
		After treatment	9.45 ± 5.99	2.12 ± 1.81
		The difference before and after treatment	2.72 ± 2.18	1.48 ± 0.75

Table 3 Comparison of Montreal Cognitive Assessment Scale scores before and after treatment between the two groups

Group	Experiment group (n = 40)		Control group (n = 40)
	Before treatment	After treatment	Before treatment	After treatment
MoCA total score 30	18.25 ± 2.34	20.43 ± 2.65	17.65 ± 2.16	16.53 ± 1.98
Memory ability 5	2.75 ± 0.81	3.15 ± 0.96	2.64 ± 0.79	2.40 ± 0.73
Verbal fluency 3	2.13 ± 0.78	2.52 ± 0.92	2.06 ± 0.77	1.97 ± 0.72
Visuospatial execution ability 5	2.98 ± 0.59	3.27 ± 0.70	2.87 ± 0.61	2.71 ± 0.58
Naming capability3	2.10 ± 0.81	2.30 ± 0.85	2.07 ± 0.79	1.94 ± 0.77
Attention and calculation ability 6	3.05 ± 0.78	3.42 ± 0.84	3.01 ± 0.76	2.74 ± 0.72
Orientation ability 6	4.02 ± 0.89	4.45 ± 0.93	3.94 ± 0.85	3.79 ± 0.81
Ability of abstraction and generalization 2	1.09 ± 0.45	1.31 ± 0.56	1.04 ± 0.49	0.95 ± 0.42

Table 4 The Quality of Life Rating Scale (QOLIE-31) score before and after treatment and the difference between the two groups

Group	Sample size	Period	QOLIE-31 score
Experiment group	40	Before treatment	43.32 ± 7.45
		After treatment	51.46 ± 8.12
		The difference before and after treatment	9.44 ± 5.23
Control group	40	Before treatment	44.56 ± 6.92
		After treatment	48.42 ± 7.83
		The difference before and after treatment	4.26 ± 4.78