Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment

Table 1 Correlation analysis of exosomal miR-320e levels with clinical assessment results in cerebral small vessel disease patients

Variable	Spearman correlation coefficient	P value
MoCA score	0.328	0.003
EFA score	0.301	0.006
HAMD score	-0.296	0.007
BDI score	-0.283	0.010

MoCA: Montreal Cognitive Assessment; EFA: Executive Function Assessment; HAMD: Hamilton Depression Scale; BDI: Beck Depression Inventory.

Table 2 miRNA levels by groups of more and less severe symptoms of cognitive impairment or depress in cerebral small vessel disease patients, n (%)

Assessment Scale	More severe disease (below the average score)		Less severe disease (beyond the average score)		P value of miRNA-levels
	Patients	miRNA level	Patients	miRNA level
MoCA	45 (56.25)	1.18 ± 0.32	35 (43.75)	2.15 ± 0.45	0.010
EFA	40 (50)	1.25 ± 0.40	40 (50)	2.30 ± 0.50	0.0092
HAMD	50 (62.5)	1.10 ± 0.35	30 (37.5)	2.20 ± 0.55	0.030
BDI	38 (47.5)	1.15 ± 0.38	42 (52.5)	2.25 ± 0.48	0.0012

MoCA: Montreal Cognitive Assessment; EFA: Executive Function Assessment; HAMD: Hamilton Depression Scale; BDI: Beck Depression Inventory.