Role of astrocytes in the development and progression of major depressive disorder

doi:10.5498/wjp.v16.i5.115794

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May 19, 2026 (publication date) through May 5, 2026

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. May 19, 2026; 16(5): 115794
Published online May 19, 2026. doi: 10.5498/wjp.v16.i5.115794

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Figure 1 Multifunctional schematic diagram of astrocytes associated with major depressive disorder. RGC: Radial glial cell; mGluRs: Metabotropic glutamate receptors; GLT-1: Glutamate transporter 1; 5-HT: 5-hydroxytryptamine; ROS: Reactive oxygen species; cGAS-STING: Cyclic GMP-AMP synthase-stimulator of interferon genes; IL-6: Interleukin-6; IL-6R: Interleukin-6 receptor; TCA: Tricarboxylic acid cycle; BDNF: Brain-derived neurotrophic factor; GDNF: Glial cell line-derived neurotrophic factor; FGF2: Fibroblast growth factor 2; VEGF: Vascular endothelial growth factor; MDD: Major depressive disorder.

Citation: Jing P, Sun C, Yin XP, Liu XC, Tian Q, Zhang XB. Role of astrocytes in the development and progression of major depressive disorder. World J Psychiatry 2026; 16(5): 115794
URL: https://www.wjgnet.com/2220-3206/full/v16/i5/115794.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i5.115794

Jing P, Sun C, Yin XP, Liu XC, Tian Q, Zhang XB. Role of astrocytes in the development and progression of major depressive disorder. World J Psychiatry 2026; 16(5): 115794 [DOI: 10.5498/wjp.v16.i5.115794]

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