Non-coding RNA in extracellular vesicles and the occurrence and progression of psychiatric disorders: A narrative review

doi:10.5498/wjp.v16.i2.113037

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Feb 19, 2026 (publication date) through Feb 2, 2026

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Feb 19, 2026; 16(2): 113037
Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.113037

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Figure 1 Schematic diagram of extracellular vesicles-mediated psychiatric disorders. External stress influences the expression of intracellular non-coding RNAs, which are precisely packaged into exosomes. Due to the load diversity of exosomes and their ability to bi-directionally penetrate the blood-brain barrier, they have emerged as potential non-invasive biomarkers for the screening, diagnosis, and treatment of brain disorders. SCZ: Schizophrenia; MDD: Major depressive disorder; BD: Bipolar disorder; BBB: Blood-brain barrier; MiRNA: MicroRNA; CircRNA: Circular RNA; LncRNA: Long non-coding RNA; MVB: Multivesicular body.

Citation: Cao Y, Li PF, Zhu L, Li K, He KJ. Non-coding RNA in extracellular vesicles and the occurrence and progression of psychiatric disorders: A narrative review. World J Psychiatry 2026; 16(2): 113037
URL: https://www.wjgnet.com/2220-3206/full/v16/i2/113037.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i2.113037